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Original article
IPMNs with co-occurring invasive cancers: neighbours but not always relatives
  1. Matthäus Felsenstein1,2,
  2. Michaël Noë1,
  3. David L Masica3,4,
  4. Waki Hosoda1,
  5. Peter Chianchiano1,
  6. Catherine G Fischer1,
  7. Gemma Lionheart1,
  8. Lodewijk A A Brosens5,
  9. Antonio Pea6,
  10. Jun Yu7,
  11. Georgios Gemenetzis7,
  12. Vincent P Groot7,8,
  13. Martin A Makary7,
  14. Jin He7,
  15. Matthew J Weiss7,
  16. John L Cameron7,
  17. Christopher L Wolfgang7,
  18. Ralph H Hruban1,9,
  19. Nicholas J Roberts1,
  20. Rachel Karchin3,4,
  21. Michael G Goggins1,9,
  22. Laura D Wood1,9
  1. 1 Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  2. 2 Department of Surgery, Charité—Universitätsmedizin Berlin, Berlin, Germany
  3. 3 Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, USA
  4. 4 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA
  5. 5 Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
  6. 6 Department of Surgery, University and Hospital Trust of Verona, Verona, Italy
  7. 7 Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  8. 8 Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
  9. 9 Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  1. Correspondence to Dr Laura D Wood, Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA; ldwood{at}jhmi.edu

Footnotes

  • Contributors MF and LDW designed the study. MF, MN, PC, CGF, GL, LAAB, AP, JY, GG, VPG, MAM, JH, MJW, JLC and CLW collected data. MF, MN, DLM, WH, RHH, NJR, RK, MGG and LDW analysed and interpreted data. MF and LDW wrote the paper. All authors contributed to critical revision and approved of the final version.

  • Funding The authors acknowledge the following sources of support: NIH/NCI P50 CA62924; NIH/NIDDK K08 DK107781; Sol Goldman Pancreatic Cancer Research Center; DFG-German Research Foundation; Buffone Family Gastrointestinal Cancer Research Fund; Kaya Tuncer Career Development Award in Gastrointestinal Cancer Prevention; AGA-Bernard Lee Schwartz Foundation Research Scholar Award in Pancreatic Cancer; Sidney Kimmel Foundation for Cancer Research Kimmel Scholar Award; AACR-Incyte Corporation Career Development Award for Pancreatic Cancer Research; Rolfe Pancreatic Cancer Foundation; Joseph C Monastra Foundation; The Gerald O Mann Charitable Foundation (Harriet and Allan Wulfstat, Trustees); Dutch Digestive Foundation (CDG 14-02); The Lisa Waller Hayes Foundation; The Nijbakker-Morra Foundation.

  • Competing interests LDW is a paid consultant for Personal Genome Diagnostics. The other authors declare no competing interests.

  • Ethics approval Johns Hopkins Hospital Institutional Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors MF and LDW designed the study. MF, MN, PC, CGF, GL, LAAB, AP, JY, GG, VPG, MAM, JH, MJW, JLC and CLW collected data. MF, MN, DLM, WH, RHH, NJR, RK, MGG and LDW analysed and interpreted data. MF and LDW wrote the paper. All authors contributed to critical revision and approved of the final version.

  • Funding The authors acknowledge the following sources of support: NIH/NCI P50 CA62924; NIH/NIDDK K08 DK107781; Sol Goldman Pancreatic Cancer Research Center; DFG-German Research Foundation; Buffone Family Gastrointestinal Cancer Research Fund; Kaya Tuncer Career Development Award in Gastrointestinal Cancer Prevention; AGA-Bernard Lee Schwartz Foundation Research Scholar Award in Pancreatic Cancer; Sidney Kimmel Foundation for Cancer Research Kimmel Scholar Award; AACR-Incyte Corporation Career Development Award for Pancreatic Cancer Research; Rolfe Pancreatic Cancer Foundation; Joseph C Monastra Foundation; The Gerald O Mann Charitable Foundation (Harriet and Allan Wulfstat, Trustees); Dutch Digestive Foundation (CDG 14-02); The Lisa Waller Hayes Foundation; The Nijbakker-Morra Foundation.

  • Competing interests LDW is a paid consultant for Personal Genome Diagnostics. The other authors declare no competing interests.

  • Ethics approval Johns Hopkins Hospital Institutional Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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