Article Text

PDF

IDDF2018-ABS-0203 Modulation of intestinal dysbiosis in patients with constipation-predominant irritable bowel syndrome using lactobacillus-containing cultured milk drink
  1. Norfilza Mokhtar,
  2. Norhayati Md Jaafar,
  3. Seow-Neng Chan,
  4. Rafiz Abdul Rani,
  5. Liyana Zaharuddin,
  6. Norshafila Diana Mohd Rathi
  1. Universiti Kebangsaan Malaysia, Malaysia

Abstract

Background Dysbiosis of gut microbiota is postulated to play a role in the pathogenesis of irritable bowel syndrome. A safe and affordable strategy to maintain gut microbiome homeostasis is by introducing cultured milk drink. This study aimed to investigate the effects of lactobacillus-containing cultured milk drink on clinical symptoms and circulating pro-inflammatory cytokines in subjects with constipation-predominant irritable bowel syndrome (IBS-C) as compared to controls.

Methods Subjects fulfilling Rome III criteria for IBS-C were recruited. Each subject had to drink three bottles of 12=cultured milk drink daily for 30 days, each containing 109 cfu of live bacteria consists of Lactobacillus acidophilus and Lactobacillus paracasei with 4.06 g/10=of fructose, 4.14 g/10=glucose, 0.29 g/10=sucrose,<0.1 g/10=maltose and 1.35 g/10=lactose. Intestinal transit time (ITT), clinical symptoms (Garrigues questionnaire), stool pH and serum IL-6, IL-8 and TNF-α were assessed at pre and post 30 day consumption.

Results About 77 IBS-C with 88 controls (mean age: 29.71±8.79 and 29.27±7.64 years old respectively) were recruited. At 30 days of post-consumption, majority (97.4%) of IBS-C had improvement in constipation-related symptoms, and faecal pH was significantly reduced from 6.13±0.57 to 5.94±0.37 (p<0.05). ITT showed significant improvement in IBS-C group (45.82±28.89 to 30.64±20.07 hours) as well as in control group (15.73±9.28 to 10.82±5.34 hours) (p<0.05). Interestingly, there was also a significant difference in ITT between these groups (p<0.05). In IBS-C, the levels of TNF- α and IL-6 were significantly lower in post as compared to pre-consumption IBS-C group (p<0.05). While for IL-8, the level was significantly reduced post-consumption in IBS-C and controls (p<0.05).

Conclusions Daily consumption of cultured milk drinks for 30 days is beneficial to improve constipation-related symptoms, reduces faecal pH, ITT and pro-inflammatory cytokines among IBS-C patients. Consideration should be made to include cultured milk drink as an option in the treatment of IBS-C.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.