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IDDF2018-ABS-0030 Clinical and histological features of patients with alcoholic liver disease
  1. Le Thi Thu Hein
  1. Internal Medicine, University of Medicine and Pharmacy, Thai Nguyen, Vietnam

Abstract

Background Alcohol-attributable burden on global health is increasing, and the relationship between population alcohol consumption and liver-related deaths is strong. Longstanding scientific and clinical work has led to a relatively thorough, if not complete, understanding of the effects of alcohol consumption on the liver. Clinical and histological features of alcoholic liver disease (ALD) are used to assist clinicians in diagnosing and determining the severity of disease in patients with ALD. In this study, we provide salient points on their clinical and histological features. In addition, the benefits of liver biopsy and important differential diagnoses, including features distinguishing these entities.

Aims This study intends to describe in detail the clinical and histological features of ALD.

Methods Liver biopsy was required for the diagnosis of histologic ALD. A total of 83 patients with ALD were included in the study. Evaluate the stage of liver fibrosis according to Metavir classification (F0,F1,F2,F3,F4). Clinical and laboratory parameters were recorded.

Results The average age was 51.41±9.69 years, the age group of 40–49 accounted for 43.4%. 83 patients included in the study were males. Clinical symptoms were hepatomegaly (62.7%), jaundice (67.5%). Histological results were mostly fatty liver (92.8%), significant fibrosis (F≥F2) accounted for 63.9%, foamy degeneration accounted for 84.3%, megamitochondria accounted for 63.4% and Mallory bodies accounted for 60.2%.

Conclusions Patients in working age were often common. Common clinical symptoms were hepatomegaly and jaundice. The patients had salient points on histological features of ALD such as foamy degeneration, megamitochondria, Mallory body, fatty liver, significant fibrosis liver, widespread neutrophilic infiltration. Liver biopsy played an important role in the real-time clinical assessment of patients. Tissue histology not only yields diagnostic information but also important information about the patient‘s overall disease progression.

  • Clinical
  • histology
  • alcoholic liver disease

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