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Original article
Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo
  1. Katja Giersch1,
  2. Oliver D Bhadra1,
  3. Tassilo Volz1,
  4. Lena Allweiss1,
  5. Kristoffer Riecken2,
  6. Boris Fehse2,
  7. Ansgar W Lohse1,3,
  8. Joerg Petersen4,
  9. Camille Sureau5,
  10. Stephan Urban3,6,
  11. Maura Dandri1,3,
  12. Marc Lütgehetmann7
  1. 1 I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  2. 2 Department of Stem Cell transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  3. 3 German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel and Heidelberg Partner sites, Germany
  4. 4 IFI Institute for Interdisciplinary Medicine, Asklepios Clinic St. Georg, Hamburg, Germany
  5. 5 Laboratoirede Virologie Moleculaire, INTS, Centre National de la Recherche Scientifique, Paris, France
  6. 6 Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany
  7. 7 Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  1. Correspondence to Dr Maura Dandri, Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany; m.dandri{at}uke.de and Dr Marc Lütgehetmann, Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany ; m.luetgehetmann{at}uke.de

Footnotes

  • KG, ODB, MD and ML contributed equally.

  • Contributors ML and MD initiated and supervised the study. ML, MD, KG and ODB designed experiments and analysed data. KG, LA and TV generated chimeric mice and analysed data. ODB and KG performed virological and immunohistological analyses. KR and BF provided HepG2 (human hepatoma)-hNTCP (human sodium taurocholate cotransporting polypeptide) cells and red green blue-marked HepG2-hNTCP cells. CS provided infectious hepatitis delta virus. SU provided Myrcludex-B. KG, ODB, MD and ML wrote the manuscript. KR, BF, AWL, JP, CS and SU discussed the data and corrected the manuscript.

  • Funding The study was supported by the German Research Foundation (DFG) by a grant to MD, ML and BF (SFB 841 A5, A8, SP2) and a Heisenberg Professorship to MD (DA1063/3-2). MD and SU also received funding from the German Center for Infection Research (DZIF-BMBF; TTU-hepatitis 05.806,05.807 and 05.704). All funding sources supporting the work are acknowledged and authors have nothing to disclose.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • KG, ODB, MD and ML contributed equally.

  • Contributors ML and MD initiated and supervised the study. ML, MD, KG and ODB designed experiments and analysed data. KG, LA and TV generated chimeric mice and analysed data. ODB and KG performed virological and immunohistological analyses. KR and BF provided HepG2 (human hepatoma)-hNTCP (human sodium taurocholate cotransporting polypeptide) cells and red green blue-marked HepG2-hNTCP cells. CS provided infectious hepatitis delta virus. SU provided Myrcludex-B. KG, ODB, MD and ML wrote the manuscript. KR, BF, AWL, JP, CS and SU discussed the data and corrected the manuscript.

  • Funding The study was supported by the German Research Foundation (DFG) by a grant to MD, ML and BF (SFB 841 A5, A8, SP2) and a Heisenberg Professorship to MD (DA1063/3-2). MD and SU also received funding from the German Center for Infection Research (DZIF-BMBF; TTU-hepatitis 05.806,05.807 and 05.704). All funding sources supporting the work are acknowledged and authors have nothing to disclose.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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