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We read with great interest the article by Villumsen et al 1 about the association between inflammatory bowel disease (IBD) and Parkinson’s disease (PD). Villumsen et al estimated the risk of developing PD to be 22% higher in a Danish IBD population than in a non-IBD population.
During the last decade, evidence has accumulated that shared biological mechanisms are involved in the development of IBD and PD.2 However, the clinical co-occurrence of IBD and PD has only been investigated to a limited extent and with inconsistent results.3–5 Thus, concerns have been raised about how best to interpret this possible association.
In a recently published article by our group, we too demonstrated a positive association between PD and IBD.6 We observed that Swedish patients with IBD were at 30% higher risk of subsequently developing PD than were non-IBD individuals. Furthermore, that patients with IBD had higher …
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