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We read with interest the recent paper by Colombel et al 1 showing that vedolizumab is frequently used for patients with inflammatory bowel disease (IBD). There is evidence for an exposure–efficacy relationship for vedolizumab induction therapy.2 Increasing dosing frequency of vedolizumab to every 4 weeks leads to an improvement in clinical response in both ulcerative colitis (UC)3 and Crohn’s disease (CD).4 In contrast to anti-tumour necrosis factor (TNF) agents, the correlation between the response to dose optimisation and changes in the pharmacokinetic profile of vedolizumab-treated patients remains unknown. We performed a retrospective analysis of all vedolizumab-treated …
CG and LP contributed equally.
Contributors CG and LP collected data, interpreted data and drafted the manuscript. HR and CB performed statistical analysis, interpreted data and critically revised the manuscript. CZ collected data and critically revised the manuscript. LP-B designed the study, interpreted data and critically revised the manuscript.
Competing interests CG, LP, HR, CZ and CB have nothing to disclose. LP-B received consulting fees from Merck, AbbVie, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillotts, Vifor, Pharmacosmos, BMS, UCB-Pharma, Hospira, Celltrion, Takeda, Biogaran, Boehringer-Ingelheim, Lilly, Pfizer, HAC-Pharma, Index Pharmaceuticals, Amgen, Sandoz, Forward Pharma GmbH, Celgene, Biogen, Lycera and Samsung Bioepis and received lecture fees from Merck, AbbVie, Takeda, Janssen, Ferring, Norgine, Tillotts, Vifor, Mitsubishi and HAC-Pharma.
Provenance and peer review Not commissioned; internally peer reviewed.
Data sharing statement There are no additional unpublished data from the study available.
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