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Early changes in the pharmacokinetic profile of vedolizumab-treated patients with IBD may predict response after dose optimisation

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  • CG and LP contributed equally.

  • Contributors CG and LP collected data, interpreted data and drafted the manuscript. HR and CB performed statistical analysis, interpreted data and critically revised the manuscript. CZ collected data and critically revised the manuscript. LP-B designed the study, interpreted data and critically revised the manuscript.

  • Competing interests CG, LP, HR, CZ and CB have nothing to disclose. LP-B received consulting fees from Merck, AbbVie, Janssen, Genentech, Mitsubishi, Ferring, Norgine, Tillotts, Vifor, Pharmacosmos, BMS, UCB-Pharma, Hospira, Celltrion, Takeda, Biogaran, Boehringer-Ingelheim, Lilly, Pfizer, HAC-Pharma, Index Pharmaceuticals, Amgen, Sandoz, Forward Pharma GmbH, Celgene, Biogen, Lycera and Samsung Bioepis and received lecture fees from Merck, AbbVie, Takeda, Janssen, Ferring, Norgine, Tillotts, Vifor, Mitsubishi and HAC-Pharma.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data sharing statement There are no additional unpublished data from the study available.

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