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Intestinal inflammation
Original article
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

Authors

  • Judith Kraiczy Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Komal M Nayak Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Kate J Howell Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Alexander Ross Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK Anne McLaren Laboratory & Department of Surgery, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Jessica Forbester Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Camilla Salvestrini Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK PubMed articlesGoogle scholar articles
  • Roxana Mustata Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Genetics, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Sally Perkins Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK PubMed articlesGoogle scholar articles
  • Amanda Andersson-Rolf Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Genetics, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Esther Leenen Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Anke Liebert Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Ludovic Vallier Anne McLaren Laboratory & Department of Surgery, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Philip C Rosenstiel Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articlesGoogle scholar articles
  • Oliver Stegle European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Gordon Dougan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Robert Heuschkel Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK PubMed articlesGoogle scholar articles
  • Bon-Kyoung Koo Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Genetics, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Matthias Zilbauer Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Bon-Kyoung Koo, Wellcome Trust MRC Stem Cell InstituteUniversity of Cambridge,Tennis Court Road, Cambridge,CB2 1QR, UK; bkk25{at}cam.ac.uk and Dr Matthias Zilbauer, Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Box 116, Cambridge,CB2 0QQ, UK; mz304{at}medschl.cam.ac.uk
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Citation

Kraiczy J, Nayak KM, Howell KJ, et al
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development
Gut 2019;68:49-61.

Publication history

  • Received July 10, 2017
  • Revised October 6, 2017
  • Accepted October 15, 2017
  • First published November 15, 2017.
Online issue publication 
June 15, 2020

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2019. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/