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Original article
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

Authors

  • Judith Kraiczy Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Komal M Nayak Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Kate J Howell Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Alexander Ross Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK Anne McLaren Laboratory & Department of Surgery, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Jessica Forbester Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Camilla Salvestrini Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK PubMed articlesGoogle scholar articles
  • Roxana Mustata Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Genetics, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Sally Perkins Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK PubMed articlesGoogle scholar articles
  • Amanda Andersson-Rolf Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Genetics, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Esther Leenen Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Anke Liebert Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK PubMed articlesGoogle scholar articles
  • Ludovic Vallier Anne McLaren Laboratory & Department of Surgery, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Philip C Rosenstiel Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articlesGoogle scholar articles
  • Oliver Stegle European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Gordon Dougan Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK PubMed articlesGoogle scholar articles
  • Robert Heuschkel Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK PubMed articlesGoogle scholar articles
  • Bon-Kyoung Koo Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Genetics, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Matthias Zilbauer Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, UK Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Bon-Kyoung Koo, Wellcome Trust MRC Stem Cell InstituteUniversity of Cambridge,Tennis Court Road, Cambridge,CB2 1QR, UK; bkk25{at}cam.ac.uk and Dr Matthias Zilbauer, Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Box 116, Cambridge,CB2 0QQ, UK; mz304{at}medschl.cam.ac.uk
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Citation

Kraiczy J, Nayak KM, Howell KJ, et al
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development

Publication history

  • Received July 10, 2017
  • Revised October 6, 2017
  • Accepted October 15, 2017
  • First published November 15, 2017.
Online issue publication 
December 07, 2018

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