Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity

Hannelie Korf; Johannie du Plessis; Jos van Pelt; Sofie De Groote; David Cassiman; Len Verbeke; Bart Ghesquière; Sarah-Maria Fendt; Matthew J Bird; Ali Talebi; Matthias Van Haele; Rita Feio-Azevedo; Lore Meelberghs; Tania Roskams; Rajeshwar P Mookerjee; Gautam Mehta; Rajiv Jalan; Thierry Gustot; Wim Laleman; Frederik Nevens; Schalk Willem van der Merwe

doi:10.1136/gutjnl-2018-316888

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Hepatology

Original article

Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity

Authors

Hannelie Korf Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Johannie du Plessis Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Department of Immunology, University of Pretoria, Pretoria, South Africa PubMed articles Google scholar articles
Jos van Pelt Department of Oncology, KU Leuven, and Leuven Cancer Institute (LKI), Leuven, Belgium PubMed articles Google scholar articles
Sofie De Groote Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
David Cassiman Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium PubMed articles Google scholar articles
Len Verbeke Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium PubMed articles Google scholar articles
Bart Ghesquière Metabolomics Expertise Centrum, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Sarah-Maria Fendt Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Leuven, Belgium Department of Oncology, Laboratory of Cellular Metabolism and Metabolic Regulation, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium PubMed articles Google scholar articles
Matthew J Bird Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Metabolomics Expertise Centrum, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Ali Talebi Department of Oncology, Laboratory of Lipid Metabolism and Cancer, KU Leuven and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Matthias Van Haele Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium PubMed articles Google scholar articles
Rita Feio-Azevedo Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Lore Meelberghs Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium PubMed articles Google scholar articles
Tania Roskams Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven and University Hospitals Leuven, Leuven, Belgium PubMed articles Google scholar articles
Rajeshwar P Mookerjee Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK PubMed articles Google scholar articles
Gautam Mehta Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK PubMed articles Google scholar articles
Rajiv Jalan Liver Failure Group, Institute for Liver Disease Health, University College London, London, UK PubMed articles Google scholar articles
Thierry Gustot Department of Gastroenterology and Hepato-Pancreatology, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium PubMed articles Google scholar articles
Wim Laleman Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium PubMed articles Google scholar articles
Frederik Nevens Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium PubMed articles Google scholar articles
Schalk Willem van der Merwe Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium PubMed articles Google scholar articles

Correspondence to Hannelie Korf; hannelie.korf{at}kuleuven.be and Professor Schalk Willem van der Merwe, Laboratory of Hepatology, Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven 3000, Belgium; schalk.vandermerwe{at}uzleuven.be

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Citation

Korf H, du Plessis J, van Pelt J, et al

Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity

Gut 2019;68:1872-1883.

Publication history

Received May 29, 2018
Revised November 27, 2018
Accepted November 29, 2018
First published December 22, 2018.

Online issue publication

September 06, 2019

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