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Original article
Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease
  1. Cyrielle Caussy1,2,
  2. Veeral H Ajmera1,
  3. Puneet Puri3,
  4. Cynthia Li-Shin Hsu1,
  5. Shirin Bassirian1,
  6. Mania Mgdsyan1,
  7. Seema Singh1,
  8. Claire Faulkner1,
  9. Mark A Valasek4,
  10. Emily Rizo1,
  11. Lisa Richards1,
  12. David A Brenner1,5,
  13. Claude B Sirlin6,
  14. Arun J Sanyal3,
  15. Rohit Loomba1,5,7
  1. 1 NAFLD Research Center, Department of Medicine, La Jolla, California, USA
  2. 2 Université Lyon 1, Hospices Civils de Lyon, Lyon, California, France
  3. 3 Virginia Commonwealth University, Richmond, Virginia, USA
  4. 4 Department of Pathology, University of California at San Diego, La Jolla, California, USA
  5. 5 Division of Gastroenterology, Department of Medicine, La Jolla, California, USA
  6. 6 Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, California, USA
  7. 7 Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California, USA
  1. Correspondence to Professor Rohit Loomba, Division of Gastroenterology and Epidemiology, University of California at San Diego, La Jolla 92093-0063, US; roloomba{at}ucsd.edu

Footnotes

  • CC, VHA and PP contributed equally.

  • Contributors CC: study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, approved final submission. VA: study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, approved final submission. PP: collection, analysis and interpretation of data, critical revision of the manuscript, approved final submission C-H: statistical analysis, critical revision of the manuscript, approved final submission SB: data collection, critical revision of the manuscript, approved final submission. MM: data collection, critical revision of the manuscript, approved final submission SS: data collection, critical revision of the manuscript, approved final submission Claire Faulkner: data collection, critical revision of the manuscript, approved final submission MAV: data collection, critical revision of the manuscript, approved final submission ER: patient visits, critical revision of the manuscript, approved final submission LR: patient visits, critical revision of the manuscript, approved final submission DAB: study concept and design, critical revision of the manuscript, study supervision, approved final submission CBS: analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, obtained funding, study supervision, approved final submission AJS: critical revision of the manuscript, approved final submission RL: study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, obtained funding, study supervision, approved final submission

  • Funding RL is supported in part by the American Gastroenterological Association (AGA) Foundation – Sucampo – ASP Designated Research Award in Geriatric Gastroenterology and by a T. Franklin Williams Scholarship Award; Funding provided by: Atlantic Philanthropies, Inc, the John A. Hartford Foundation, OM, the Association of Specialty Professors, and the American Gastroenterological Association and grant K23-DK090303. CS and RL serve as co-PIs on the grant R01-DK106419. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. VA is supported by the AASLD Foundation Clinical and Translational Research Award. CC is supported by grants from the Société Francophone du Diabète (SFD), the Philippe Foundation and Monahan Foundation under the Fulbright program.

  • Competing interests CBS consults, advises and is on the speakers’ bureau for Bayer. He received grants from GE Healthcare

  • Patient consent Not required.

  • Ethics approval This study was Health Insurance Portability and Accountability Act (HIPAA) compliant and was approved by the UCSD Institutional Review Board 111282.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • CC, VHA and PP contributed equally.

  • Contributors CC: study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, approved final submission. VA: study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, approved final submission. PP: collection, analysis and interpretation of data, critical revision of the manuscript, approved final submission C-H: statistical analysis, critical revision of the manuscript, approved final submission SB: data collection, critical revision of the manuscript, approved final submission. MM: data collection, critical revision of the manuscript, approved final submission SS: data collection, critical revision of the manuscript, approved final submission Claire Faulkner: data collection, critical revision of the manuscript, approved final submission MAV: data collection, critical revision of the manuscript, approved final submission ER: patient visits, critical revision of the manuscript, approved final submission LR: patient visits, critical revision of the manuscript, approved final submission DAB: study concept and design, critical revision of the manuscript, study supervision, approved final submission CBS: analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, obtained funding, study supervision, approved final submission AJS: critical revision of the manuscript, approved final submission RL: study concept and design, analysis and interpretation of data, drafting of the manuscript, critical revision of the manuscript, obtained funding, study supervision, approved final submission

  • Funding RL is supported in part by the American Gastroenterological Association (AGA) Foundation – Sucampo – ASP Designated Research Award in Geriatric Gastroenterology and by a T. Franklin Williams Scholarship Award; Funding provided by: Atlantic Philanthropies, Inc, the John A. Hartford Foundation, OM, the Association of Specialty Professors, and the American Gastroenterological Association and grant K23-DK090303. CS and RL serve as co-PIs on the grant R01-DK106419. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. VA is supported by the AASLD Foundation Clinical and Translational Research Award. CC is supported by grants from the Société Francophone du Diabète (SFD), the Philippe Foundation and Monahan Foundation under the Fulbright program.

  • Competing interests CBS consults, advises and is on the speakers’ bureau for Bayer. He received grants from GE Healthcare

  • Patient consent Not required.

  • Ethics approval This study was Health Insurance Portability and Accountability Act (HIPAA) compliant and was approved by the UCSD Institutional Review Board 111282.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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