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Hepatology
Original article
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas

Authors

  • Qi Zhang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Yu Lou Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Jiaqi Yang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Junli Wang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Jie Feng Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Yali Zhao Novogene Biotechnology Inc, Beijing, China PubMed articlesGoogle scholar articles
  • Lin Wang Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Xing Huang Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Qihan Fu Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Mao Ye Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Xiaozhen Zhang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Yiwen Chen Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Ce Ma Novogene Biotechnology Inc, Beijing, China PubMed articlesGoogle scholar articles
  • Hongbin Ge Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Jianing Wang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Jiangchao Wu Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Tao Wei Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Qi Chen Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Junqing Wu Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Chengxuan Yu Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Yanyu Xiao Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Xinhua Feng Life Sciences Institute Zhejiang University, Hangzhou, China PubMed articlesGoogle scholar articles
  • Guoji Guo Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China PubMed articlesGoogle scholar articles
  • Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  • Xueli Bai Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, China PubMed articlesGoogle scholar articles
  1. Correspondence to Prof Tingbo Liang and Dr Xueli Bai, Department of Hepatobiliary and Pancreatic Surgery Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, China ; liangtingbo{at}zju.edu.cn, shirleybai{at}zju.edu.cn
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Citation

Zhang Q, Lou Y, Yang J, et al
Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas
Gut 2019;68:2019-2031.

Publication history

  • Received April 15, 2019
  • Revised May 21, 2019
  • Accepted May 29, 2019
  • First published June 21, 2019.
Online issue publication 
November 22, 2019

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.