Article Text

Download PDFPDF
Original article
Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial
  1. Yoriko Heianza1,
  2. Dianjianyi Sun1,
  3. Xiang Li1,
  4. Joseph A DiDonato2,
  5. George A Bray3,
  6. Frank M Sacks4,
  7. Lu Qi1,4
  1. 1 Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA
  2. 2 Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
  3. 3 Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
  4. 4 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  1. Correspondence to Professor Lu Qi, Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA; lqi1{at}tulane.edu

Footnotes

  • Contributors YH contributed to the study concept and design, analysis and interpretation of data, drafting and revising the manuscript, statistical analysis and study supervision. DS and XL contributed analysis and interpretation of data, and drafting and revising the manuscript. JAD contributed measurements and interpretation of data, and drafting and revising the manuscript. GAB and FMS contributed to acquisition of data, interpretation of data and drafting and revising the manuscript. LQ contributed to the study concept and design, acquisition of data, analysis and interpretation of data, drafting and revising the manuscript, statistical analysis and funding and study supervision. LQ had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  • Funding The study is supported by National Institutes of Health (NIH) grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), the National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616), the Boston Obesity Nutrition Research Center (DK46200) and USA–Israel Binational Science Foundation Grant 2011036. LQ was a recipient of the American Heart Association Scientist Development Award (0730094N). YH is a recipient of a Grant-in-Aid for Scientific Research and Postdoctoral Fellowship for Research Abroad from the Japan Society for the Promotion of Science.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The trial was conducted at two sites, one in Boston at the Harvard School of Public Health and Brigham & Women’s Hospital and the other in Baton Rouge at the Pennington Biomedical Research Center of the Louisiana State University System.The study was approved by the human subjects committee at each institution and by data and safety monitoring board appointed by the National Heart, Lung and Blood Institute. All participants gave written informed consent.

  • Provenance and peer review Not commissioned; externally peer reviewed.

View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors YH contributed to the study concept and design, analysis and interpretation of data, drafting and revising the manuscript, statistical analysis and study supervision. DS and XL contributed analysis and interpretation of data, and drafting and revising the manuscript. JAD contributed measurements and interpretation of data, and drafting and revising the manuscript. GAB and FMS contributed to acquisition of data, interpretation of data and drafting and revising the manuscript. LQ contributed to the study concept and design, acquisition of data, analysis and interpretation of data, drafting and revising the manuscript, statistical analysis and funding and study supervision. LQ had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  • Funding The study is supported by National Institutes of Health (NIH) grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), the National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616), the Boston Obesity Nutrition Research Center (DK46200) and USA–Israel Binational Science Foundation Grant 2011036. LQ was a recipient of the American Heart Association Scientist Development Award (0730094N). YH is a recipient of a Grant-in-Aid for Scientific Research and Postdoctoral Fellowship for Research Abroad from the Japan Society for the Promotion of Science.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The trial was conducted at two sites, one in Boston at the Harvard School of Public Health and Brigham & Women’s Hospital and the other in Baton Rouge at the Pennington Biomedical Research Center of the Louisiana State University System.The study was approved by the human subjects committee at each institution and by data and safety monitoring board appointed by the National Heart, Lung and Blood Institute. All participants gave written informed consent.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.