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Original article
Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis
  1. Jun Ho Lee1,
  2. Jae Hee Suh2,
  3. Soo Youn Choi1,
  4. Hyun Je Kang1,
  5. Hwan Hee Lee1,
  6. Byeong Jin Ye1,
  7. Gap Ryol Lee3,
  8. Seok Won Jung4,
  9. Chang Jae Kim1,
  10. Whaseon Lee-Kwon1,
  11. Jiyoung Park1,
  12. Kyungjae Myung1,5,
  13. Neung Hwa Park4,
  14. Hyug Moo Kwon1,5
  1. 1 School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea
  2. 2 Department of Pathology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Republic of Korea
  3. 3 Department of Life Science, Sogang University, Seoul, Republic of Korea
  4. 4 Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Republic of Korea
  5. 5 Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea
  1. Correspondence to Professor Neung Hwa Park, Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan 44033, Republic of Korea; nhparkmd{at}gmail.com and Professor Hyug Moo Kwon, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea; hmkwon{at}unist.ac.kr

Footnotes

  • Contributors JHL, NHP and HMK conceived, directed and interpreted results and wrote the manuscript. JHL designed, performed and analysed most of the experiments. SYC helped to design and to interpret results and wrote the manuscript. JHS performed histological analysis and performed and analysed tissue array and IHC. NHP and JHS provided human HCC samples. HJK, HHL, BJY, SWJ and CJK contributed to the performance experiments. GRL provided YY1 constructs. KM, WL-K and JP provided intellectual input. NHP and HMK supervised experiments.

  • Funding This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government (Ministry of Science and ICT) (NRF-2011-0020163, NRF-2010-0029621, NRF-2016R1D1A1B03932335, NRF-2012R1A1A2043693, NRF-2017R1E1A1A01074673), Health Technology R&D Project grant of Korea (HI16C1837) and the Institute for Basic Science (IBS-R022-D1-2016) of Korea. This work was also supported by UNIST fund (1.170068.01). JHL was supported by Global PhD Fellowship of Korea (NRF-2014H1A2A1019656).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This research was approved by the Institutional Review Board at the Ulsan University Hospital (UUH 2015-12-018).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors JHL, NHP and HMK conceived, directed and interpreted results and wrote the manuscript. JHL designed, performed and analysed most of the experiments. SYC helped to design and to interpret results and wrote the manuscript. JHS performed histological analysis and performed and analysed tissue array and IHC. NHP and JHS provided human HCC samples. HJK, HHL, BJY, SWJ and CJK contributed to the performance experiments. GRL provided YY1 constructs. KM, WL-K and JP provided intellectual input. NHP and HMK supervised experiments.

  • Funding This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government (Ministry of Science and ICT) (NRF-2011-0020163, NRF-2010-0029621, NRF-2016R1D1A1B03932335, NRF-2012R1A1A2043693, NRF-2017R1E1A1A01074673), Health Technology R&D Project grant of Korea (HI16C1837) and the Institute for Basic Science (IBS-R022-D1-2016) of Korea. This work was also supported by UNIST fund (1.170068.01). JHL was supported by Global PhD Fellowship of Korea (NRF-2014H1A2A1019656).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval This research was approved by the Institutional Review Board at the Ulsan University Hospital (UUH 2015-12-018).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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