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Original article
Efficacy of pharmacological therapies for the treatment of opioid-induced constipation: systematic review and network meta-analysis
  1. Pavit Luthra1,2,
  2. Nicholas E Burr1,2,
  3. Darren M Brenner3,
  4. Alexander C Ford1,2
  1. 1 Leeds Gastroenterology Institute, St. James’s University Hospital, Leeds, UK
  2. 2 Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK
  3. 3 Division of Gastroenterology and Hepatology, Northwestern University – Feinberg School of Medicine, Chicago, Illinois, USA
  1. Correspondence to Professor Alexander C Ford, Leeds Gastroenterology Institute, St. James’s University Hospital, Leeds LS9 7TF, UK; alexf12399{at}yahoo.com

Footnotes

  • PL and NEB are joint first authors

  • Contributors PL, NEB, DMB and ACF conceived and drafted the study. ACF and PL collected all data. ACF and NEB analysed and interpreted the data. ACF, PL and NEB drafted the manuscript. ACF is guarantor. All authors commented on drafts of the paper. All authors have approved the final draft of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests PL, NEB and ACF: none declared. DMB has acted as a consultant, advisor and speaker for Synergy, Allergan, Ironwood, AstraZeneca, Daiichi Sankyo, Shionogi, Salix Pharmaceuticals, Medscape LLC, Medtronic and GI Health Foundation.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it published Online First. The joint author statement has been added.

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Footnotes

  • PL and NEB are joint first authors

  • Contributors PL, NEB, DMB and ACF conceived and drafted the study. ACF and PL collected all data. ACF and NEB analysed and interpreted the data. ACF, PL and NEB drafted the manuscript. ACF is guarantor. All authors commented on drafts of the paper. All authors have approved the final draft of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests PL, NEB and ACF: none declared. DMB has acted as a consultant, advisor and speaker for Synergy, Allergan, Ironwood, AstraZeneca, Daiichi Sankyo, Shionogi, Salix Pharmaceuticals, Medscape LLC, Medtronic and GI Health Foundation.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it published Online First. The joint author statement has been added.

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