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Tight junction proteins in gastrointestinal and liver disease
  1. Mirjam B Zeisel1,2,3,
  2. Punita Dhawan4,5,6,
  3. Thomas F Baumert2,3,7
  1. 1 Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL), Lyon, France
  2. 2 Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France
  3. 3 Université de Strasbourg, Strasbourg, France
  4. 4 Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA
  5. 5 Buffet Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska, USA
  6. 6 VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska, USA
  7. 7 Nouvel Hôpital Civil, Pôle Hépato-digestif, Institut Hospitalo-Universitaire, Strasbourg, France
  1. Correspondence to Dr Mirjam B Zeisel, Inserm U1052, CNRS UMR 5286, Cancer Research Center of Lyon (CRCL), Université de Lyon (UCBL), Lyon 69424, France; mirjam.zeisel{at}inserm.fr, Dr Punita Dhawan, University of Nebraska for Medical Sciences, 985870 Nebraska Medical Center, Omaha, NE 68198-5870 ; punita.dhawan{at}unmc.edu and Dr Thomas F Baumert, Inserm U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, 3 rue Koeberlé, 67000 Strasbourg, France ; thomas.baumert{at}unistra.fr

Footnotes

  • Contributors MBZ, PD and TFB wrote the manuscript.

  • Funding The authors’ work is supported by ARC, Paris and Institut Hospitalo-Universitaire, Strasbourg (TheraHCC IHUARC IHU201301187), the European Union (ERC-AdG-HEPCIR, ERC-PoC-2016-PRELICAN, EU H2020-667273-HEPCAR, U Strasbourg Foundation HEPKIN), the National Institutes of Health (NCI 1R21CA209940-01A1, NIAID R03AI131066, NIAID 5U19AI123862-02), the Institut Universitaire de France (IUF), the IdEx Program of the University of Strasbourg, the Impulsion Program of the IDEXLYON, BX002086 (VA merit), CA216746 (NIH/NCI) and a pilot project award from Fred and Pamela Buffet Cancer Center, which is funded by a National Cancer Institute Cancer Center Support Grant under award number P30 CA036727. This work has been published under the framework of the LABEX ANR-10-LABX-0028_HEPSYS and benefits from funding from the state managed by the French National Research Agency as part of the investments for the future programme.

  • Competing interests TFB is a coinventor of a patent/patent application of CLDN1-specific antibodies for prevention and treatment of HCV infection. TFB and MBZ are coinventors of patent applications for anti-claudin 1 monoclonal antibodies for the prevention and treatment of liver disease and HCC.

  • Patient consent Not required.

  • Provenance and peer review Commissioned; externally peer reviewed.

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Footnotes

  • Contributors MBZ, PD and TFB wrote the manuscript.

  • Funding The authors’ work is supported by ARC, Paris and Institut Hospitalo-Universitaire, Strasbourg (TheraHCC IHUARC IHU201301187), the European Union (ERC-AdG-HEPCIR, ERC-PoC-2016-PRELICAN, EU H2020-667273-HEPCAR, U Strasbourg Foundation HEPKIN), the National Institutes of Health (NCI 1R21CA209940-01A1, NIAID R03AI131066, NIAID 5U19AI123862-02), the Institut Universitaire de France (IUF), the IdEx Program of the University of Strasbourg, the Impulsion Program of the IDEXLYON, BX002086 (VA merit), CA216746 (NIH/NCI) and a pilot project award from Fred and Pamela Buffet Cancer Center, which is funded by a National Cancer Institute Cancer Center Support Grant under award number P30 CA036727. This work has been published under the framework of the LABEX ANR-10-LABX-0028_HEPSYS and benefits from funding from the state managed by the French National Research Agency as part of the investments for the future programme.

  • Competing interests TFB is a coinventor of a patent/patent application of CLDN1-specific antibodies for prevention and treatment of HCV infection. TFB and MBZ are coinventors of patent applications for anti-claudin 1 monoclonal antibodies for the prevention and treatment of liver disease and HCC.

  • Patient consent Not required.

  • Provenance and peer review Commissioned; externally peer reviewed.

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