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Commentary
Immunosuppressive βig-h3 links tumour stroma and dysfunctional T cells in pancreatic cancer
  1. Christian Alexander Bauer
  1. Correspondence to Dr Christian Alexander Bauer, Klinik für Gastroenterologie, Endokrinologie, Infektiologie und Stoffwechsel, Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg, Marburg 35043, Germany; chr.bauer{at}uni-marburg.de

https://doi.org/10.1136/gutjnl-2018-317735

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    Recent FDA approval of anti-PD-1 antibody pembrolizumab as a site-agnostic therapy for mismatch repair (MMR)–deficient solid tumours has highlighted the importance of CD8+ T cell responses and the potential of immunotherapy, even in tumour entities that are traditionally considered poor candidates for immune-based therapies, such as pancreatic carcinoma.1 Clearly, the old dogma of immunologically cold pancreatic carcinoma has to be refined.

    It has been known for long that higher levels of intratumoural CD8+ cytotoxic T lymphocytes (CTLs) correlate with better survival of patients with pancreatic carcinoma.2 3 However, in most pancreatic carcinomas, endogenous CD8+ T cells are relatively sparse.4 Moreover, intratumoural macrophages, myeloid-derived suppressor cells and regulatory T cells (Tregs) dominate even the earliest …

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    Footnotes

    • Contributors CAB has drafted and written the manuscript.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Patient consent for publication Not required.

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      Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer
      Delphine Goehrig Jérémy Nigri Rémi Samain Zhichong Wu Paola Cappello Gaëlle Gabiane Xinyi Zhang Yajie Zhao In-San Kim Marie Chanal Roberta Curto Valerie Hervieu Christelle de La Fouchardière Francesco Novelli Pascale Milani Richard Tomasini Corinne Bousquet Philippe Bertolino Ana Hennino
      Gut 2018; 68 693-707 Published Online First: 10 Nov 2018. doi: 10.1136/gutjnl-2018-317570