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Original article
Impact of thiopurines on the natural history and surgical outcome of ulcerative colitis: a cohort study
  1. Carl Eriksson1,
  2. Sara Rundquist1,
  3. Yang Cao2,3,
  4. Scott Montgomery2,4,5,
  5. Jonas Halfvarson1
  1. 1 Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  2. 2 Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden
  3. 3 Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  4. 4 Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
  5. 5 Department of Epidemiology and Public Health, University College London, London, UK
  1. Correspondence to Dr Carl Eriksson, Department of Gastroenterology, Faculty of Medicine and HealthÖrebro, University, Örebro SE-70182, Sweden; carl.eriksson{at}regionorebrolan.se

Footnotes

  • Contributors CE, JH and SM planned and conducted the study. CE and SR collected the data. CE and YC performed the data analyses. CE, JH, SM, SR and YC interpreted the data. CE and JH drafted the manuscript. CE, JH, SM and YC revised the manuscript. CE, JH, SM, SR and YC approved the final draft of the manuscript.

  • Funding CE was financially supported by the Swedish government’s agreement on medical training and research (OLL-549221).

  • Competing interests CE: research grant from the Swedish government’s agreement on medical training and research and speaker’s fee from Takeda. JH: research grants from the Swedish Research Council, the Örebro University Hospital Research Foundation, the Swedish Foundation for Strategic Research and speaker’s and/or consultancy fees from Abbvie, Hospira, Janssen, Medivir, MSD, Pfizer, RenapharmaVifor and Takeda.

  • Patient consent Not required.

  • Ethics approval The study was approved by the Uppsala Regional Ethics Committee in 2010 (approval no. 2010/304).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors CE, JH and SM planned and conducted the study. CE and SR collected the data. CE and YC performed the data analyses. CE, JH, SM, SR and YC interpreted the data. CE and JH drafted the manuscript. CE, JH, SM and YC revised the manuscript. CE, JH, SM, SR and YC approved the final draft of the manuscript.

  • Funding CE was financially supported by the Swedish government’s agreement on medical training and research (OLL-549221).

  • Competing interests CE: research grant from the Swedish government’s agreement on medical training and research and speaker’s fee from Takeda. JH: research grants from the Swedish Research Council, the Örebro University Hospital Research Foundation, the Swedish Foundation for Strategic Research and speaker’s and/or consultancy fees from Abbvie, Hospira, Janssen, Medivir, MSD, Pfizer, RenapharmaVifor and Takeda.

  • Patient consent Not required.

  • Ethics approval The study was approved by the Uppsala Regional Ethics Committee in 2010 (approval no. 2010/304).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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