Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

Jeanne Tie; Joshua D Cohen; Yuxuan Wang; Lu Li; Michael Christie; Koen Simons; Hany Elsaleh; Suzanne Kosmider; Rachel Wong; Desmond Yip; Margaret Lee; Ben Tran; David Rangiah; Matthew Burge; David Goldstein; Madhu Singh; Iain Skinner; Ian Faragher; Matthew Croxford; Carolyn Bampton; Andrew Haydon; Ian T Jones; Christos S Karapetis; Timothy Price; Mary J Schaefer; Jeanne Ptak; Lisa Dobbyn; Natallie Silliman; Isaac Kinde; Cristian Tomasetti; Nickolas Papadopoulos; Kenneth Kinzler; Bert Volgestein; Peter Gibbs

doi:10.1136/gutjnl-2017-315852

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Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

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Jeanne Tie Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Joshua D Cohen Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Yuxuan Wang Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Lu Li Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Michael Christie Department of Pathology, Melbourne Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Koen Simons Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Hany Elsaleh Department of Radiation Oncology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia PubMed articles Google scholar articles
Suzanne Kosmider Department of Medical Oncology, Western Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Rachel Wong Department of Medical Oncology, Eastern Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Desmond Yip Department of Medical Oncology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia PubMed articles Google scholar articles
Margaret Lee Department of Medicine, Melbourne Medical School—Western Precinct, The University of Melbourne, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Ben Tran Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia PubMed articles Google scholar articles
David Rangiah Department of Surgery, The Canberra Hospital, Canberra, Australian Capital Territory, Australia PubMed articles Google scholar articles
Matthew Burge Department of Medical Oncology, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia PubMed articles Google scholar articles
David Goldstein Department of Medical Oncology, Prince of Wales Hospital, Sydney, New South Wales, Australia PubMed articles Google scholar articles
Madhu Singh Department of Medical Oncology, Barwon Health, Geelong, Australia PubMed articles Google scholar articles
Iain Skinner Department of Surgery, Western Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Ian Faragher Department of Surgery, Western Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Matthew Croxford Department of Surgery, Western Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Carolyn Bampton Department of Medical Oncology, Adelaide Cancer Centre, Adelaide, South Australia, Australia PubMed articles Google scholar articles
Andrew Haydon Department of Medical Oncology, Alfred Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Ian T Jones Department of Surgery, Melbourne Health, Melbourne, Victoria, Australia PubMed articles Google scholar articles
Christos S Karapetis Flinders Centre for Innovation in Cancer, Flinders Medical Centre and Flinders University, Adelaide, South Australia, Australia PubMed articles Google scholar articles
Timothy Price Department of Medical Oncology, Queen Elizabeth Hospital, Adelaide, South Australia, Australia PubMed articles Google scholar articles
Mary J Schaefer Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Jeanne Ptak Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Lisa Dobbyn Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Natallie Silliman Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Isaac Kinde Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Cristian Tomasetti Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Nickolas Papadopoulos Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Kenneth Kinzler Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Bert Volgestein Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA PubMed articles Google scholar articles
Peter Gibbs Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia PubMed articles Google scholar articles

Correspondence to Associate Professor Jeanne Tie, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia; Jeanne.Tie{at}petermac.org

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Citation

Tie J, Cohen JD, Wang Y, et al

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study

Gut 2019;68:663-671.

Publication history

Received December 13, 2017
Revised January 15, 2018
Accepted January 18, 2018
First published February 2, 2018.

Online issue publication

March 07, 2019

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