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  • Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

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Original article
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Authors

  • Tamsin R M Lannagan School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Young K Lee School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Tongtong Wang School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Jatin Roper The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA Division of Gastroenterology, Tufts Medical Center, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Mark L Bettington Envoi Specialist Pathologists, Brisbane, Queensland, Australia Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia PubMed articlesGoogle scholar articles
  • Lochlan Fennell Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia School of Health and Sports Science, University of the Sunshine Coast, Brisbane, Queensland, Australia PubMed articlesGoogle scholar articles
  • Laura Vrbanac School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Lisa Jonavicius Department of Anatomical Pathology, Flinders Medical Centre, Bedford Park, South Australia, Australia PubMed articlesGoogle scholar articles
  • Roshini Somashekar School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Krystyna Gieniec School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Miao Yang School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Jia Q Ng School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Nobumi Suzuki School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Mari Ichinose School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Josephine A Wright School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Hiroki Kobayashi School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Tracey L Putoczki Department of Medical Biology, University of Melbourne and the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Yoku Hayakawa Department of Gastroenterology, University of Tokyo, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Simon J Leedham Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK Gastrointestinal Stem Cell Biology Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
  • Helen E Abud Cancer Program, Monash Biomedicine Discovery Institute and the Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia PubMed articlesGoogle scholar articles
  • Ömer H Yilmaz The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Julie Marker Cancer Voices SA, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Sonja Klebe Department of Anatomical Pathology, Flinders Medical Centre, Bedford Park, South Australia, Australia PubMed articlesGoogle scholar articles
  • Pratyaksha Wirapati Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Siddhartha Mukherjee Department of Medicine, Columbia University Medical Center, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Sabine Tejpar Digestive Oncology Unit, Department of Oncology, University Hospitals Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Barbara A Leggett Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia Royal Brisbane and Womens Hospital, Brisbane, Queensland, Australia School of Medicine, University of Queensland, Brisbane, Queensland, Australia PubMed articlesGoogle scholar articles
  • Vicki L J Whitehall Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia School of Medicine, University of Queensland, Brisbane, Queensland, Australia Pathology Queensland, Brisbane, Queensland, Australia PubMed articlesGoogle scholar articles
  • Daniel L Worthley School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Susan L Woods School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Daniel L Worthley, South Australian Health & Medical Research Institute, Adelaide SA, Australia; Dan.Worthley{at}sahmri.com and Dr Susan L Woods, School of Medicine, University of Adelaide and South Australian Health and Medical Research Institute, Adelaide, SA 5005, Australia; susan.woods{at}adelaide.edu.au
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Citation

Lannagan TRM, Lee YK, Wang T, et al
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
Gut 2019;68:684-692.

Publication history

  • Received December 27, 2017
  • Revised March 14, 2018
  • Accepted March 27, 2018
  • First published April 17, 2018.
Online issue publication 
March 07, 2019

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