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  • Assessing the ProMCol classifier as a prognostic marker for non-metastatic colorectal cancer within the Melbourne Collaborative Cohort Study

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Assessing the ProMCol classifier as a prognostic marker for non-metastatic colorectal cancer within the Melbourne Collaborative Cohort Study

https://doi.org/10.1136/gutjnl-2018-316122

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    Footnotes

    • MCS and DDB contributed equally.

    • Contributors This study was first conceived by JEJ, HJ and DDB. EMW and JEJ performed laboratory experiments. JEJ and HJ performed bioinformatics and statistical analysis. HJ, DRE, RLM, GGG and DDB faciliated the inclusion of the data from the MCCS. MC and CR provided molecular characterisation and paghological review of FFPE slides, respectively. The manuscript was first constructed by JEJ, HJ and DDB. MC, CR, IMW, MAJ, JLH, DRE, RLM, GGG and MCS provided critical reviews of the analysis and the manuscript. All authors reviewed and approved the final manuscript.

    • Funding This project was supported by grant from the National Health and Medical Research Council (NHMRC) (grant 1027505). MCCS recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. Cases were ascertained through the Victorian Cancer Registry (VCR) and the Australian Cancer Database (Australian Institute of Health and Welfare). HJ is supported by a Victorian Cancer Agency Early Career Seed Grant Fellowship. MCS is a Senior Research Fellow and JLH is a Senior Principle Research Fellow of the NHMRC. DDB is a NHMRC RD Wright Biomedical Fellow.

    • Disclaimer Authors had full responsibility for the design of the study, the collection of the data, the analysis and interpretaion of the data, the decision to submit the manuscript for publication and the writing of the manuscript.

    • Competing interests None declared.

    • Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

    • Ethics approval This study was approved by the Cancer Council Victoria Human Research Ethics Committee (IEC No. 9001).

    • Provenance and peer review Not commissioned; externally peer reviewed.