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Long-term proton pump inhibitors use and risk of gastric cancer: a meta-analysis of 926 386 participants
  1. Qian-Yi Wan1,
  2. Xiao-Ting Wu1,
  3. Ni Li2,
  4. Liang Du3,
  5. Yong Zhou1
  1. 1 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
  2. 2 Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China
  3. 3 Chinese Evidence-Based Medicine/Cochrane Center, Chengdu, China
  1. Correspondence to Professor Yong Zhou, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China; nutritioner{at}

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We read with interest the study by Cheung et al1 reporting that long-term use of proton pump inhibitors (PPIs) was associated with an increased risk of gastric cancer (GC) in participants after Helicobacter pylori eradication. Considering PPIs were widely used for the treatment of acid-related disorders, and previous studies about PPIs use and risk of GC did not have a consistent result. To better understand this issue, we conducted this meta-analysis that investigated the associations between long-term PPIs use and risk of GC.

We searched the PubMed, Embase and Web of Science for potential studies published before March 2018. …

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  • Contributors Q-YW, X-TW and NL are co-first authors. YZ and Q-YW designed the study. All the authors contributed to the generation, collection, assembly, analysis and/ or interpretation of data. Q-YW and NL wrote the manuscript under the guidance of YZ. All the authors have read manuscript, and X-TW and LD approved the final manuscript.

  • Funding This work was supported by Chinese Medical Board Grant on Evidence-Based Medicine, New York, USA (no. 98-680), National Natural Science Foundation of China (no. 30901427) and Sichuan Provincial Science and Technology Support Project (2016SZ0047).

  • Competing interests None declared.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Data sharing statement Data are available for sharing for scientific purposes.