Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

Clemens Schafmayer; James William Harrison; Stephan Buch; Christina Lange; Matthias C Reichert; Philipp Hofer; François Cossais; Juozas Kupcinskas; Witigo von Schönfels; Bodo Schniewind; Wolfgang Kruis; Jürgen Tepel; Myrko Zobel; Jonas Rosendahl; Thorsten Jacobi; Andreas Walther-Berends; Michael Schroeder; Ilka Vogel; Petr Sergeev; Hans Boedeker; Holger Hinrichsen; Andreas Volk; Jens-Uwe Erk; Greta Burmeister; Alexander Hendricks; Sebastian Hinz; Sebastian Wolff; Martina Böttner; Andrew R Wood; Jessica Tyrrell; Robin N Beaumont; Melanie Langheinrich; Torsten Kucharzik; Stefanie Brezina; Ursula Huber-Schönauer; Leonora Pietsch; Laura Sophie Noack; Mario Brosch; Alexander Herrmann; Raghavan Veera Thangapandi; Hans Wolfgang Schimming; Sebastian Zeissig; Stefan Palm; Gerd Focke; Anna Andreasson; Peter T Schmidt; Juergen Weitz; Michael Krawczak; Henry Völzke; Gernot Leeb; Patrick Michl; Wolfgang Lieb; Robert Grützmann; Andre Franke; Frank Lammert; Thomas Becker; Limas Kupcinskas; Mauro D’Amato; Thilo Wedel; Christian Datz; Andrea Gsur; Michael N Weedon; Jochen Hampe

doi:10.1136/gutjnl-2018-317619

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Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

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Clemens Schafmayer Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany PubMed articles Google scholar articles
James William Harrison University of Exeter Medical School, University of Exeter, United Kingdom, Exeter, UK PubMed articles Google scholar articles
Stephan Buch Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Christina Lange Institute of Anatomy, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Matthias C Reichert Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany PubMed articles Google scholar articles
Philipp Hofer Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria PubMed articles Google scholar articles
François Cossais Institute of Anatomy, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Juozas Kupcinskas Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articles Google scholar articles
Witigo von Schönfels Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Bodo Schniewind General Hospital Lüneburg, Lüneburg, Germany PubMed articles Google scholar articles
Wolfgang Kruis Department of Internal Medicine, Gastroenterology and Pulmonology, Evangelic Hospital Köln-Kalk, Cologne, Germany PubMed articles Google scholar articles
Jürgen Tepel Department of General and Thoracic Surgery, Hospital Osnabrück, Osnabrück, Germany PubMed articles Google scholar articles
Myrko Zobel Department of Gastroenterology, Helios Hospital Weißeritztal, Freital, Germany PubMed articles Google scholar articles
Jonas Rosendahl Medical Department 1, University Hospital Halle, Martin-Luther Universität Halle-Wittenberg, Halle, Germany PubMed articles Google scholar articles
Thorsten Jacobi Diakonissenanstalt, Hospital Dresden, Dresden, Germany PubMed articles Google scholar articles
Andreas Walther-Berends Gastroenterology Outpatient Center Fördepraxis, Kiel, Germany PubMed articles Google scholar articles
Michael Schroeder Center for Gastroenterology and Hepatology, Kiel, Germany PubMed articles Google scholar articles
Ilka Vogel Department of Surgery, Community Hospital Kiel, Kiel, Germany PubMed articles Google scholar articles
Petr Sergeev Department of Internal Medicine II, Hospital Riesa, Kiel, Germany PubMed articles Google scholar articles
Hans Boedeker Department of Internal Medicine, Hospital Freiberg, Freiberg, Germany PubMed articles Google scholar articles
Holger Hinrichsen Center for Gastroenterology and Hepatology, Kiel, Germany PubMed articles Google scholar articles
Andreas Volk Department of Visceral, Thoracic and Vascular Surgery, Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Jens-Uwe Erk Medical Department 1, University Hospital Halle, Martin-Luther Universität Halle-Wittenberg, Halle, Germany PubMed articles Google scholar articles
Greta Burmeister Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Alexander Hendricks Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Sebastian Hinz Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Sebastian Wolff Department of Internal Medicine, Gastroenterology and Pulmonology, Evangelic Hospital Köln-Kalk, Cologne, Germany PubMed articles Google scholar articles
Martina Böttner Institute of Anatomy, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Andrew R Wood University of Exeter Medical School, University of Exeter, United Kingdom, Exeter, UK PubMed articles Google scholar articles
Jessica Tyrrell University of Exeter Medical School, University of Exeter, United Kingdom, Exeter, UK PubMed articles Google scholar articles
Robin N Beaumont University of Exeter Medical School, University of Exeter, United Kingdom, Exeter, UK PubMed articles Google scholar articles
Melanie Langheinrich Department of Surgery, University Hospital Erlangen, Erlangen, Germany PubMed articles Google scholar articles
Torsten Kucharzik General Hospital Lüneburg, Lüneburg, Germany PubMed articles Google scholar articles
Stefanie Brezina Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria PubMed articles Google scholar articles
Ursula Huber-Schönauer Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private Medical University of Salzburg, Oberndorf, Austria PubMed articles Google scholar articles
Leonora Pietsch Medical Department 1, University Hospital Halle, Martin-Luther Universität Halle-Wittenberg, Halle, Germany PubMed articles Google scholar articles
Laura Sophie Noack Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Mario Brosch Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Alexander Herrmann Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Raghavan Veera Thangapandi Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Hans Wolfgang Schimming Department of Gastroenterology, Helios Hospital Weißeritztal, Freital, Germany PubMed articles Google scholar articles
Sebastian Zeissig Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Stefan Palm Outpatient Center for Gastroenterology, Dippoldiswalde, Germany PubMed articles Google scholar articles
Gerd Focke Outpatient Center for Gastroenterology Dresden-Blasewitz, Dresden, Germany PubMed articles Google scholar articles
Anna Andreasson Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden Stress Research Institute, Stockholm University, Stockholm, Sweden PubMed articles Google scholar articles
Peter T Schmidt Department of Medicine Solna and Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Juergen Weitz Department of Visceral, Thoracic and Vascular Surgery, Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles
Michael Krawczak Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Henry Völzke Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany PubMed articles Google scholar articles
Gernot Leeb Department of Gastroenterology, Hospital Oberpullendorf, Oberpullendorf, Austria PubMed articles Google scholar articles
Patrick Michl Medical Department 1, University Hospital Halle, Martin-Luther Universität Halle-Wittenberg, Halle, Germany PubMed articles Google scholar articles
Wolfgang Lieb Institute of Epidemiology & Popgen Biobank, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Robert Grützmann Department of Surgery, University Hospital Erlangen, Erlangen, Germany PubMed articles Google scholar articles
Andre Franke Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany PubMed articles Google scholar articles
Frank Lammert Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany PubMed articles Google scholar articles
Thomas Becker Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Limas Kupcinskas Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articles Google scholar articles
Mauro D’Amato Department of Medicine Solna and Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden PubMed articles Google scholar articles
Thilo Wedel Institute of Anatomy, Kiel University, Kiel, Germany PubMed articles Google scholar articles
Christian Datz Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private Medical University of Salzburg, Oberndorf, Austria PubMed articles Google scholar articles
Andrea Gsur Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria PubMed articles Google scholar articles
Michael N Weedon University of Exeter Medical School, University of Exeter, United Kingdom, Exeter, UK PubMed articles Google scholar articles
Jochen Hampe Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden), Dresden, Germany PubMed articles Google scholar articles

Correspondence to Professor Jochen Hampe, Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden 01307, Germany; jochen.hampe{at}uniklinikum-dresden.de

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Citation

Schafmayer C, Harrison JW, Buch S, et al

Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms

Gut 2019;68:854-865.

Publication history

Received September 18, 2018
Revised January 3, 2019
Accepted January 5, 2019
First published January 19, 2019.

Online issue publication

April 08, 2019

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