Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

Pavel Strnad; Stephan Buch; Karim Hamesch; Janett Fischer; Jonas Rosendahl; Renate Schmelz; Stefan Brueckner; Mario Brosch; Carolin V Heimes; Vivien Woditsch; David Scholten; Hans Dieter Nischalke; Sabina Janciauskiene; Mattias Mandorfer; Michael Trauner; Michael J Way; Andrew McQuillin; Matthias C Reichert; Marcin Krawczyk; Markus Casper; Frank Lammert; Felix Braun; Witigo von Schönfels; Sebastian Hinz; Greta Burmeister; Claus Hellerbrand; Andreas Teufel; Alexandra Feldman; Joern M Schattenberg; Heike Bantel; Anita Pathil; Muenevver Demir; Johannes Kluwe; Tobias Boettler; Monika Ridinger; Norbert Wodarz; Michael Soyka; Marcella Rietschel; Falk Kiefer; Thomas Weber; Silke Marhenke; Arndt Vogel; Holger Hinrichsen; Ali Canbay; Martin Schlattjan; Katharina Sosnowsky; Christoph Sarrazin; Johann von Felden; Andreas Geier; Pierre Deltenre; Bence Sipos; Clemens Schafmayer; Michael Nothnagel; Elmar Aigner; Christian Datz; Felix Stickel; Marsha Yvonne Morgan; Jochen Hampe; Thomas Berg; Christian Trautwein

doi:10.1136/gutjnl-2018-316228

Article info

Hepatology

Original article

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

Authors

Pavel Strnad Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany Coordinating Center for Alpha1-antitrypsin Deficiency-related Liver Disease of the European Reference Network (ERN) ’Rare Liver', European Association for the Study of the Liver (EASL) Registry Group ’Alpha1-Liver', Aachen, Germany PubMed articles Google scholar articles
Stephan Buch Medical Department 1, University Hospital Dresden, Dresden, Germany PubMed articles Google scholar articles
Karim Hamesch Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany Coordinating Center for Alpha1-antitrypsin Deficiency-related Liver Disease of the European Reference Network (ERN) ’Rare Liver', European Association for the Study of the Liver (EASL) Registry Group ’Alpha1-Liver', Aachen, Germany PubMed articles Google scholar articles
Janett Fischer Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Jonas Rosendahl Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany Department of Internal Medicine I, University Hospital Halle, Martin Luther University, Halle, Germany PubMed articles Google scholar articles
Renate Schmelz Medical Department 1, University Hospital Dresden, Dresden, Germany PubMed articles Google scholar articles
Stefan Brueckner Medical Department 1, University Hospital Dresden, Dresden, Germany PubMed articles Google scholar articles
Mario Brosch Medical Department 1, University Hospital Dresden, Dresden, Germany PubMed articles Google scholar articles
Carolin V Heimes Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany PubMed articles Google scholar articles
Vivien Woditsch Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany PubMed articles Google scholar articles
David Scholten Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany PubMed articles Google scholar articles
Hans Dieter Nischalke Department of Internal Medicine I, University of Bonn, Bonn, Germany PubMed articles Google scholar articles
Sabina Janciauskiene Clinic for Pneumology, German Center for Lung Research (DZL), Medical University Hannover, Hannover, Germany PubMed articles Google scholar articles
Mattias Mandorfer Clinic for Gastroenterology und Hepatology, Medical University Vienna, Vienna, Austria PubMed articles Google scholar articles
Michael Trauner Clinic for Gastroenterology und Hepatology, Medical University Vienna, Vienna, Austria PubMed articles Google scholar articles
Michael J Way Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK PubMed articles Google scholar articles
Andrew McQuillin Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK PubMed articles Google scholar articles
Matthias C Reichert Department of Medicine II, Saarland University Medical Center, Homburg, Germany PubMed articles Google scholar articles
Marcin Krawczyk Department of Medicine II, Saarland University Medical Center, Homburg, Germany Laboratory of Metabolic Liver Diseases, Department of General, Transplantation and Liver Surgery, Medical University of Warsaw, Warsaw, Poland PubMed articles Google scholar articles
Markus Casper Department of Medicine II, Saarland University Medical Center, Homburg, Germany PubMed articles Google scholar articles
Frank Lammert Department of Medicine II, Saarland University Medical Center, Homburg, Germany PubMed articles Google scholar articles
Felix Braun Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Witigo von Schönfels Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Sebastian Hinz Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Greta Burmeister Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Claus Hellerbrand Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany PubMed articles Google scholar articles
Andreas Teufel Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany PubMed articles Google scholar articles
Alexandra Feldman Department of Internal Medicine I, University Hospital Salzburg, Salzburg, Austria PubMed articles Google scholar articles
Joern M Schattenberg Department of Medicine I, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany PubMed articles Google scholar articles
Heike Bantel Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Anita Pathil Department of Internal Medicine IV, Gastroenterology and Hepatology, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Muenevver Demir Clinic for Gastroenterology and Hepatology, University Hospital of Cologne, Cologne, Germany PubMed articles Google scholar articles
Johannes Kluwe I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Tobias Boettler Department of Medicine II, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany PubMed articles Google scholar articles
Monika Ridinger Department of Psychology, University of Konstanz, Konstanz, Germany PubMed articles Google scholar articles
Norbert Wodarz Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany PubMed articles Google scholar articles
Michael Soyka Psychiatric Hospital, Ludwig Maximilians University, Munich, Germany PubMed articles Google scholar articles
Marcella Rietschel Faculty of Medicine Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany PubMed articles Google scholar articles
Falk Kiefer Faculty of Medicine Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany PubMed articles Google scholar articles
Thomas Weber Department for Clinical Research, University Hospital Bern, Bern, Switzerland PubMed articles Google scholar articles
Silke Marhenke Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Arndt Vogel Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Holger Hinrichsen Department of Gastroenterology, University Hospital Kiel, Kiel, Germany PubMed articles Google scholar articles
Ali Canbay Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany Department of Gastroenterology and Hepatology, University Duisburg-Essen, Essen, Germany PubMed articles Google scholar articles
Martin Schlattjan Department of Gastroenterology and Hepatology, University Duisburg-Essen, Essen, Germany PubMed articles Google scholar articles
Katharina Sosnowsky Department of Internal Medicine 1, J.W. Goethe University Hospital Frankfurt, Frankfurt, Germany PubMed articles Google scholar articles
Christoph Sarrazin Department of Internal Medicine 1, J.W. Goethe University Hospital Frankfurt, Frankfurt, Germany PubMed articles Google scholar articles
Johann von Felden I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Andreas Geier Division of Hepatology, Department of Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany PubMed articles Google scholar articles
Pierre Deltenre Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium PubMed articles Google scholar articles
Bence Sipos Institute of Pathology, University of Tuebingen, Tuebingen, Germany PubMed articles Google scholar articles
Clemens Schafmayer Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany PubMed articles Google scholar articles
Michael Nothnagel Cologne Center for Genomics, University of Cologne, Cologne, Germany PubMed articles Google scholar articles
Elmar Aigner Department of Internal Medicine I, University Hospital Salzburg, Salzburg, Austria PubMed articles Google scholar articles
Christian Datz Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Oberndorf, Austria PubMed articles Google scholar articles
Felix Stickel Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland PubMed articles Google scholar articles
Marsha Yvonne Morgan Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK PubMed articles Google scholar articles
Jochen Hampe Medical Department 1, University Hospital Dresden, Dresden, Germany PubMed articles Google scholar articles
Thomas Berg Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Christian Trautwein Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany Coordinating Center for Alpha1-antitrypsin Deficiency-related Liver Disease of the European Reference Network (ERN) ’Rare Liver', European Association for the Study of the Liver (EASL) Registry Group ’Alpha1-Liver', Aachen, Germany PubMed articles Google scholar articles

Correspondence to Dr Thomas Berg, Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig 04103, Germany; thomas.berg{at}medizin.uni-leipzig.de

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Citation

Strnad P, Buch S, Hamesch K, et al

Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis

Gut 2019;68:1099-1107.

Publication history

Received February 8, 2018
Revised June 20, 2018
Accepted July 3, 2018
First published August 1, 2018.

Online issue publication

May 08, 2019

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