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Rare cause of rectal stenosis in a patient with long-term use of Infliximab and Mercaptopurine for ulcerative colitis
  1. Nassim Hammoudi1,
  2. Charlotte Gardair2,
  3. My-Linh Tran-Minh1,
  4. Matthieu Allez1,
  5. Jean-Marc Gornet1
  1. 1 Department of Gastroenterology, AP-HP Hôpital Saint Louis, Paris, France
  2. 2 Department of Pathology, AP-HP Hôpital Saint Louis, Paris, France
  1. Correspondence to Dr Jean-Marc Gornet, Service de Gastroentérologie, Hôpital Saint Louis, Paris 75010, France; jean-marc.gornet{at}

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A 58-year-old, non-smoker male patient with no family history was followed up since 2002 for ulcerative colitis (UC) located in the rectosigmoid. He was initially treated by salicylates alone until November 2008. Mercaptopurine was started in August 2009 for steroid dependence with primary failure despite adequate 6 thioguanine nucleotides (6 TGN) level. He was included in February 2010 in the PURSUIT trial testing Golimumab with only partial response. A combination therapy with Mercaptopurine and Infliximab was then started in December 2010 with a long-term clinical, biological and endoscopic steroid-free remission. A pan-chromoendoscopy performed in June 2016 showed a complete mucosal healing with no histological activity …

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  • Contributors NH: writing and data collection J-MG: writing and manuscript coordination. CG: pathological examination and histological pictures providing. M-LT-M and MA: copy editing of the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Next of kin consent obtained.