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Original article
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

Authors

  • Nathalie Stakenborg Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Evelien Labeeuw Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Pedro J Gomez-Pinilla Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Sebastiaan De Schepper Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Raymond Aerts Department of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Gera Goverse Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Giovanna Farro Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Iris Appeltans Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Elisa Meroni Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Michelle Stakenborg Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Maria Francesca Viola Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Erika Gonzalez-Dominguez Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Goele Bosmans Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Yeranddy A Alpizar Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Albert Wolthuis Department of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Andre D’Hoore Department of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Kim Van Beek Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Simon Verheijden Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Marleen Verhaegen Department of Anesthesiology, University Hospital of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Rita Derua Department of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, Universitiy of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Etienne Waelkens Department of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, Universitiy of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Milena Moretti CNR, Neuroscience Institute-Milano, Biometra University of Milan, Milan, Italy PubMed articlesGoogle scholar articles
  • Cecilia Gotti CNR, Neuroscience Institute-Milano, Biometra University of Milan, Milan, Italy PubMed articlesGoogle scholar articles
  • Patrick Augustijns Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Drug Delivery and Disposition, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Karel Talavera Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Pieter Vanden Berghe Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Enteric Neuroscience, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Gianluca Matteoli Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Guy E Boeckxstaens Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Guy E Boeckxstaens, Department of Chronic Diseases, Metabolism and Ageing; Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven 3000, Belgium; guy.boeckxstaens{at}kuleuven.be
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Citation

Stakenborg N, Labeeuw E, Gomez-Pinilla PJ, et al
Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

Publication history

  • Received July 27, 2018
  • Revised October 16, 2018
  • Accepted October 18, 2018
  • First published November 24, 2018.
Online issue publication 
July 05, 2019

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