Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice

Wei-Kai Wu; Chieh-Chang Chen; Po-Yu Liu; Suraphan Panyod; Ben-Yang Liao; Pei-Chen Chen; Hsien-Li Kao; Han-Chun Kuo; Ching-Hua Kuo; Tina H T Chiu; Rou-An Chen; Hsiao-Li Chuang; Yen-Te Huang; Hsin-Bai Zou; Cheng-Chih Hsu; Ting-Yan Chang; Chin-Lon Lin; Chi-Tang Ho; Hon-Tsen Yu; Lee-Yan Sheen; Ming-Shiang Wu

doi:10.1136/gutjnl-2018-317155

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Gut microbiota

Original article

Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice

Authors

Wei-Kai Wu Department of Internal Medicine, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Chieh-Chang Chen Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan PubMed articles Google scholar articles
Po-Yu Liu Department of Life Science, National Taiwan University, Taipei, Taiwan Genome and Systems Biology Degree Program, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Suraphan Panyod Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Ben-Yang Liao Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan PubMed articles Google scholar articles
Pei-Chen Chen Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Hsien-Li Kao Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan PubMed articles Google scholar articles
Han-Chun Kuo The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Ching-Hua Kuo The Metabolomics Core Laboratory, Center of Genomic Medicine, National Taiwan University, Taipei, Taiwan School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Tina H T Chiu Department of Nutrition Therapy, Dalin Tzu Chi Hospital, Chiayi, Taiwan PubMed articles Google scholar articles
Rou-An Chen Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Hsiao-Li Chuang National Applied Research Laboratories, National Laboratory Animal Center, Taipei, Taiwan PubMed articles Google scholar articles
Yen-Te Huang National Applied Research Laboratories, National Laboratory Animal Center, Taipei, Taiwan PubMed articles Google scholar articles
Hsin-Bai Zou Department of Chemistry, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Cheng-Chih Hsu Department of Chemistry, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Ting-Yan Chang Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan PubMed articles Google scholar articles
Chin-Lon Lin Department of Internal Medicine, Dalin Tzu Chi Hospital, Taipei, Taiwan PubMed articles Google scholar articles
Chi-Tang Ho Department of Food Science, Rutgers University, New Burnswick, New Jersey, USA PubMed articles Google scholar articles
Hon-Tsen Yu Department of Life Science, National Taiwan University, Taipei, Taiwan Genome and Systems Biology Degree Program, Academia Sinica, Taipei, Taiwan PubMed articles Google scholar articles
Lee-Yan Sheen Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles
Ming-Shiang Wu Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan PubMed articles Google scholar articles

Correspondence to Professor Lee-Yan Sheen, Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; lysheen{at}ntu.edu.tw and Professor Ming-Shiang Wu, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan; mingshiang{at}ntu.edu.tw

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Citation

Wu W, Chen C, Liu P, et al

Identification of TMAO-producer phenotype and host–diet–gut dysbiosis by carnitine challenge test in human and germ-free mice

Gut 2019;68:1439-1449.

Publication history

Received July 9, 2018
Revised October 8, 2018
Accepted October 11, 2018
First published October 30, 2018.

Online issue publication

July 05, 2019

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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