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Original article
DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth
  1. Jeroni Luna1,2,
  2. Jacopo Boni2,3,
  3. Miriam Cuatrecasas1,4,5,
  4. Xavier Bofill-De Ros1,2,
  5. Estela Núñez-Manchón1,
  6. Meritxell Gironella1,4,
  7. Eva C Vaquero1,4,
  8. Maria L Arbones2,6,
  9. Susana de la Luna2,3,7,8,
  10. Cristina Fillat1,2,9
  1. 1 Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
  2. 2 Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Barcelona, Spain
  3. 3 Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain
  4. 4 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
  5. 5 Departament de Patologia, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic de Barcelona i Banc de Tumors-Biobanc Clinic-IDIBAPS, Barcelona, Spain
  6. 6 Institut de Biologia Molecular de Barcelona (IBMB), Barcelona, Spain
  7. 7 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
  8. 8 Universitat Pompeu Fabra (UPF), Barcelona, Spain
  9. 9 Universitat de Barcelona (UB), Barcelona, Spain
  1. Correspondence to Dr Susana de la Luna, Centre for Genomic Regulation (CRG), Barcelona 08003, Spain; susana.luna{at}crg.eu and Dr Cristina Fillat, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona 08036, Spain; cfillat{at}clinic.ub.es

Footnotes

  • SL and CF share senior authorship.

  • JL and JB contributed equally.

  • Contributors JL and JB designed and performed the experiments, analysed the data and gave input to the manuscript; MC analysed human histological samples; XB-DR performed computational analysis; EN-M performed experiments; MG provided RNA samples of patients with PDAC; ECV and MLA provided KPC and Dyrk1a +/- mice; SdlL and CF devised the project, coordinated the work, analysed data and wrote the manuscript. All authors approved the manuscript.

  • Funding This work was supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) (BIO2014-57716-C2-2-R, BIO2017-89754-C2-2R to CF and BFU2016-76141-P to SL), and receives partial support from the Generalitat de Catalunya (SGR14/248 to CF and SGR14/674 to SL). CIBER de Enfermedades Raras and de Enfermedades Hepáticas y Digestivas are initiatives of the Instituto de Salud Carlos III (ISCIII). The group of CF is partially financed by the ISCIII (IIS10/00014), co-financed by Fondo Europeo de Desarrollo Regional (FEDER), and acknowledges the support of the COST Action BM1204 EUPancreas. MG acknowledges grant PI17/01003 from ISCIII.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The study was approved by the HCB Institutional Ethics Committee. All animal procedures met the guidelines of European Community Directive 86/609/EEC and were approved by the Ethical Committee (CEEA-University of Barcelona) and by the local authorities (Generalitat de Catalunya).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • SL and CF share senior authorship.

  • JL and JB contributed equally.

  • Contributors JL and JB designed and performed the experiments, analysed the data and gave input to the manuscript; MC analysed human histological samples; XB-DR performed computational analysis; EN-M performed experiments; MG provided RNA samples of patients with PDAC; ECV and MLA provided KPC and Dyrk1a +/- mice; SdlL and CF devised the project, coordinated the work, analysed data and wrote the manuscript. All authors approved the manuscript.

  • Funding This work was supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) (BIO2014-57716-C2-2-R, BIO2017-89754-C2-2R to CF and BFU2016-76141-P to SL), and receives partial support from the Generalitat de Catalunya (SGR14/248 to CF and SGR14/674 to SL). CIBER de Enfermedades Raras and de Enfermedades Hepáticas y Digestivas are initiatives of the Instituto de Salud Carlos III (ISCIII). The group of CF is partially financed by the ISCIII (IIS10/00014), co-financed by Fondo Europeo de Desarrollo Regional (FEDER), and acknowledges the support of the COST Action BM1204 EUPancreas. MG acknowledges grant PI17/01003 from ISCIII.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval The study was approved by the HCB Institutional Ethics Committee. All animal procedures met the guidelines of European Community Directive 86/609/EEC and were approved by the Ethical Committee (CEEA-University of Barcelona) and by the local authorities (Generalitat de Catalunya).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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