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Gut microbiota
Original article
International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis
  1. Alasdair J Scott1,
  2. James L Alexander1,
  3. Claire A Merrifield1,
  4. David Cunningham2,
  5. Christian Jobin3,
  6. Robert Brown1,
  7. John Alverdy4,
  8. Stephen J O’Keefe5,
  9. H Rex Gaskins6,
  10. Julian Teare1,
  11. Jun Yu7,
  12. David J Hughes8,
  13. Hans Verstraelen9,
  14. Jeremy Burton10,
  15. Paul W O’Toole11,
  16. Daniel W Rosenberg12,
  17. Julian R Marchesi1,
  18. James M Kinross1
  1. 1 Department of Surgery and Cancer, Imperial College London, London, UK
  2. 2 Gastrointestinal Unit, Royal Marsden Hospital, London, UK
  3. 3 Division of Gastroenterology, Hepatology andNutrition, University of Florida College of Medicine, Gainesville, Florida, USA
  4. 4 Department of Surgery, University of Chicago, Chicago, Illinois, USA
  5. 5 Division of Gastroenterology, Hepatology andNutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  6. 6 Carl R. Woese Institute for Genomic Biology,Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
  7. 7 Department of Medicine and Therapeutics, StateKey Laboratory of Digestive Diseases, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
  8. 8 Cancer Biology and Therapeutics Group (CBT), Conway Institute, School of Biomolecular andBiomedical Science (SBBS), University College Dublin, Dublin, Ireland
  9. 9 Department of Obstetrics and Gynaecology,Vulvovaginal Disease Clinic, Ghent University Hospital, Belgium
  10. 10 Canadian Centre for Human Microbiome and Probiotics Research, Lawson Health Research Institute, London, Ontario, Canada
  11. 11 School of Microbiology & APC MicrobiomeIreland, University College Cork, Cork, Ireland
  12. 12 Center for Molecular Oncology, University of Connecticut School of Medicine, Farmington, Connecticut, USA
  1. Correspondence to Professor Julian R Marchesi, Department of Surgery and Cancer, Imperial College London, London W2 1NY, UK; j.marchesi{at}imperial.ac.uk

Footnotes

  • Contributors AJS, JA, CAM, JMK and JM planned the consensus statement and organised the ICMC roundtable discussion, proposing broad topics for discussion. AJS, JA, CAM, JMK, JM, DC, CJ, RB, JA, SJO, HRG, JT, JY, DJH, HV, JB and DWR contributed to active discussion during the roundtable event. AJS, JA, CAM, JMK and JM drafted the manuscript. DC, CJ, RB, JA, SJO, HRG, JT, JY, DJH, HV, JB, PWO and DWR revised the manuscipt. JMK and JM act as guarantors of the content of the manuscript.

  • Funding The roundtable discussion was funded by Cancer Research UK (Award C42378/A25637). The Division of Integrative Systems Medicine and Digestive Disease at Imperial College London receives financial support from the National Institute of Health Research (NIHR) Imperial Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London. This article is independent research funded by the NIHR BRC, and the views expressed in this publication are those of the authors and not necessarily those of the NHS, NIHR, or the Department of Health.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it published Online First. The ninth author’s name has been corrected.

  • Patient consent for publication Not required.

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http://dx.doi.org/10.1136/gutjnl-2019-318556

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    Footnotes

    • Contributors AJS, JA, CAM, JMK and JM planned the consensus statement and organised the ICMC roundtable discussion, proposing broad topics for discussion. AJS, JA, CAM, JMK, JM, DC, CJ, RB, JA, SJO, HRG, JT, JY, DJH, HV, JB and DWR contributed to active discussion during the roundtable event. AJS, JA, CAM, JMK and JM drafted the manuscript. DC, CJ, RB, JA, SJO, HRG, JT, JY, DJH, HV, JB, PWO and DWR revised the manuscipt. JMK and JM act as guarantors of the content of the manuscript.

    • Funding The roundtable discussion was funded by Cancer Research UK (Award C42378/A25637). The Division of Integrative Systems Medicine and Digestive Disease at Imperial College London receives financial support from the National Institute of Health Research (NIHR) Imperial Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London. This article is independent research funded by the NIHR BRC, and the views expressed in this publication are those of the authors and not necessarily those of the NHS, NIHR, or the Department of Health.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Correction notice This article has been corrected since it published Online First. The ninth author’s name has been corrected.

    • Patient consent for publication Not required.

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    © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.