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Original article
Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade
  1. Ying Zhu1,
  2. Jing Yang1,
  3. Da Xu1,
  4. Xiao-Mei Gao2,
  5. Ze Zhang1,
  6. Jennifer L Hsu3,
  7. Chia-Wei Li3,
  8. Seung-Oe Lim3,
  9. Yuan-Yuan Sheng1,
  10. Yu Zhang1,
  11. Jian-Hua Li1,
  12. Qin Luo2,
  13. Yan Zheng1,
  14. Yue Zhao1,
  15. Lu Lu1,
  16. Hu-Liang Jia1,
  17. Mien-Chie Hung3,
  18. Qiong-Zhu Dong1,2,
  19. Lun-Xiu Qin1,2
  1. 1 Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, Shanghai, China
  2. 2 Institutes of Biomedical Sciences, Fudan University, Shanghai, China
  3. 3 Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
  1. Correspondence to Dr Mien-Chie Hung, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; mhung{at}mdanderson.org and Dr Qiong-Zhu Dong and Professor Lun-Xiu Qin, Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China; Institutes of Biomedical Sciences Fudan University, 131 Dong An Road, Shanghai 200032, China; qzhdong{at}fudan.edu.cn, qinlx{at}fudan.edu.cn

Footnotes

  • YZ, JY, DX, X-MG and ZZ contributed equally.

  • Contributors YZ, JY, DX, XM-G and ZZ designed and performed the experiments, analysed data and wrote the manuscript; JH, LL and HL-J revised the manuscript; JH-L, YY-S, QL and YZ performed experiments and analysed data; CW-L and SO-L participated in the discussion and data interpretation; YZ and YZ analysed data; LX-Q, QZ-D and MC-H designed and supervised the entire project, designed the experiments, analysed data and wrote the manuscript.

  • Funding This work was supported by the following: the National Key Research and Development Program of China (2017YFC1308604); the National Key Basic Research Program of China (2014CB542101 and 2013CB910500); National Natural Science Foundation of China (81772563, 81672820, 81372647 and 81672365); and China National Key Projects for Infectious Disease (2012ZX10002-012 and 2017ZX10203207).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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Footnotes

  • YZ, JY, DX, X-MG and ZZ contributed equally.

  • Contributors YZ, JY, DX, XM-G and ZZ designed and performed the experiments, analysed data and wrote the manuscript; JH, LL and HL-J revised the manuscript; JH-L, YY-S, QL and YZ performed experiments and analysed data; CW-L and SO-L participated in the discussion and data interpretation; YZ and YZ analysed data; LX-Q, QZ-D and MC-H designed and supervised the entire project, designed the experiments, analysed data and wrote the manuscript.

  • Funding This work was supported by the following: the National Key Research and Development Program of China (2017YFC1308604); the National Key Basic Research Program of China (2014CB542101 and 2013CB910500); National Natural Science Foundation of China (81772563, 81672820, 81372647 and 81672365); and China National Key Projects for Infectious Disease (2012ZX10002-012 and 2017ZX10203207).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Patient consent for publication Not required.

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