Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

Hong Jiang; Xiuting Liu; Brett L Knolhoff; Samarth Hegde; Kyung Bae Lee; Hongmei Jiang; Ryan C Fields; Jonathan A Pachter; Kian-Huat Lim; David G DeNardo

doi:10.1136/gutjnl-2018-317424

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Pancreas

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Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

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Hong Jiang Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China PubMed articles Google scholar articles
Xiuting Liu Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
Brett L Knolhoff Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
Samarth Hegde Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
Kyung Bae Lee Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
Hongmei Jiang Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
Ryan C Fields Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
Jonathan A Pachter Verastem Inc., Needham, MA, USA PubMed articles Google scholar articles
Kian-Huat Lim Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles
David G DeNardo Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA PubMed articles Google scholar articles

Correspondence to Dr David G DeNardo, Medicine, Washington University, St. Louis, MO 63132, USA; ddenardo{at}wustl.edu

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Jiang H, Liu X, Knolhoff BL, et al

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

Gut 2020;69:122-132.

Publication history

Received August 17, 2018
Revised April 10, 2019
Accepted April 23, 2019
First published May 10, 2019.

Online issue publication

December 06, 2019

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