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Unexplained liver dysfunction in a young Chinese man with eosinophilia
  1. Zhuwan Lyu,
  2. Qi Miao,
  3. Pan Jiang,
  4. Xiao Xiao,
  5. Xiaoyu Chen,
  6. Qixia Wang,
  7. Xiong Ma
  1. Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease; Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Jiao-Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China
  1. Correspondence to Professor Xiong Ma, Devision of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai 200001, China; maxiongmd{at}

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Clinical presentation

A 37-year-old man complained of a 7 months’ history of yellowish skin and sclera accompanied by fatigue, pruritus and dry mouth, with a history of subcutaneous masses on his elbow. Hard and fixed subcutaneous masses were noted on his palm and periauricular region, the largest of which was approximately 2 cm in diameter (figure 1A). Mildly tortuous veins on his abdominal wall above the umbilicus were detected (figure 1B). The patient had no history of liver disease. Family history was not contributory. Laboratory tests demonstrated a leucocyte count of 2.9×109/L (3.97–9.15×109/L), 7.9% eosinophil (0.5%–5%), a total bilirubin of 94.5μmol/L, gamma-glutamyl transpeptidase of 67.8 U/L (11–50 U/L) and serum IgG of 23.3 g/L (7–16 g/L), IgG4 of 3.48 g/L (0.08–1.4 g/L) and IgE of 256 IU/mL (0–100 IU/mL). Coagulation function tests revealed prothrombin time of 14.8 s (9.4–12.5 s), international normalised ratio (INR) of 1.33 and …

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  • Contributors ZL drafted the manuscript. QM and XC contributed to the description of histopathological features. PJ and XX provided clinical suggestions. QW and XM critically revised the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.