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The complicated dialogue between Helicobacter pylori and p53
  1. Zhi-Hang Tao,
  2. Jing-Yuan Fang
  1. State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  1. Correspondence to Dr Jing-Yuan Fang, State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai 200001, China; jingyuanfang{at}sjtu.edu.cn

https://doi.org/10.1136/gutjnl-2020-320630

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    We recently read the interesting paper published in GUT elucidating the role of upstream stimulatory factor 1 (USF1) in Helicobacter pylori (Hp)-induced p53 degradation.1 The work greatly broadens our knowledge of the interplay between Hp and p53 during gastric carcinogenesis. Here we propose some additional exploration, if incorporated in study design, can further deepen our understanding.

    The significance of USF1 in gastric carcinogenesis should be acknowledged as the study showed that loss of USF1, on its own, exacerbated the severity of …

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    Footnotes

    • Contributors Written by Z-HT. Revised by J-YF.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; internally peer reviewed.