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Increasing incidence of young-onset colorectal cancers in the UK and rising mortality in rectal cancers
  1. Karl King Yong1,
  2. Moe Kyaw2,
  3. Georgina Chadwick2,
  4. Krishna Sundaram2
  1. 1 Gastroenterology, London North West Healthcare NHS Trust, London, UK
  2. 2 Gastroenterology, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
  1. Correspondence to Dr Moe Kyaw, Chelsea and Westminster Healthcare NHS Trust, London, UK; moe.kyaw{at}

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We read the recent Gut publication by Vuik et al 1 reporting an increase in incidence of young-onset colorectal cancers (CRCs) in Europe over the last 25 years. However, the rise in incidence was not associated with a similar rise in mortality. This study extracted data from the national and regional European cancer registries from 20 European countries, between years 1990 and 2016. The author claimed that there is some variability among some European countries, and mortality data are not available from the UK. Therefore, we conducted a UK-specific population-based study on young colon and rectal cancer incidence and mortality.

We extracted data on young-onset colon and rectal cancer incidence and mortality between 1996 and 2016 from Cancer Research UK. Trends were analysed by Joinpoint Regression Programme expressed as average annual percentage change. Incidence of young-onset colon and rectal cancer increased significantly in both men (colon cancer: 3.9 …

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  • Contributors MK designed and supervised the study. Data were collected and analysed by KKY. The manuscript was prepared by KKY and MK. The manuscript was critically reviewed by GC and KS without editorial support. All authors read, revised and approved the final report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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