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We read with great interest the article by Hubers et al published in Gut.1 They identified annexin A11 as an autoantigen in IgG4-associated cholangitis (IAC) and autoimmune pancreatitis (AIP), which is targeted by IgG4 and IgG1 antibodies in the sera of IAC/AIP patients.1 Notably, they reported that none of the 20 patients tested for primary sclerosing cholangitis (PSC) had anti-annexin A11 antibodies. Thus, the measurement of these antibodies is helpful in differentiating IAC from PSC. In addition to the anti-annexin A11 antibodies, we recently reported another autoantibody, anti-laminin 511-E8 antibody, in patients with AIP.2 Here, we show a case of IAC/AIP with a normal serum IgG4 concentration and no infiltration of IgG4 plasma cells in the biliary duct, whose diagnosis was made by measuring the anti-laminin 511-E8 antibody.
A 57-year-old man visited our hospital in 2005 for swelling of pancreas. Contrast-enhanced CT and …
Contributors KA, YK and HS looked after the patient. MS measured anti-laminin 511-E8 antibody. KA, YK and TC wrote the report. Written consent to publish was obtained.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Kansai Electric Power Hospital Ethics Board.
Provenance and peer review Not commissioned; internally peer reviewed.
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