Footnotes

• D-TS and D-ZJ contributed equally.

• Contributors D-TS and D-ZJ are cofirst authors. H-GX and D-TS designed the study. All the authors contributed to the generation, collection, assembly, analysis and/or interpretation of data. D-TS and D-ZJ wrote the manuscript. H-GX and HG revised the manuscript. All the authors have read and approved the final manuscript.

• Funding This work was supported by the National Natural Science Foundation of China (81302531), the Natural Science Foundation of Jiangsu Province of China (SBK2018022334), the Talents Planning of Six Summit Fields of Jiangsu Province (2013-WSN-037), the Postgraduate Research and Practice Innovation Program of Jiangsu Province (KYCX17_1287, SJCX18_0435), the National Key Clinical Department of Laboratory Medicine of China in Nanjing, theKey Laboratory for Laboratory Medicine of Jiangsu Province (ZDXKB2016005) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

• Disclaimer The funder of the study had no role in the study design, data collection, data analysis, data interpretation or writing of the manuscript. The corresponding author had full access to all the data in the study and has final responsibility for the decision to submit for publication.

• Competing interests None declared.

• Provenance and peer review Not commissioned; internally peer reviewed.

• Patient consent for publication Not required.