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Letter
Response to: ‘Circulating microbiome in blood of different circulatory compartments’ by Schierwagen et al
  1. Bastian Volker Helmut Hornung1,
  2. Romy Danielle Zwittink1,
  3. Quinten Raymond Ducarmon1,
  4. Ed J Kuijper1,2
  1. 1 Center for Microbiome Analyses and Therapeutics, Department of Experimental Bacteriology, Leiden University Medical Center, Leiden, the Netherlands
  2. 2 Netherlands Donor Feces Bank, Leiden University Medical Center, Leiden, the Netherlands
  1. Correspondence to Dr Bastian Volker Helmut Hornung, Center for Microbiome Analyses and Therapeutics, Department of Experimental Bacteriology, Leiden University Medical Center, Leiden 2312KT, The Netherlands; bastian.hornung{at}gmx.de

http://dx.doi.org/10.1136/gutjnl-2019-318601

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    We read with interest the article by Schierwagen et al,1 who reported on their findings regarding the blood microbiome. Since our research group is working in a hospital setting, recently, we have also considered investigating the blood microbiome using collected blood samples that are potentially available. However, based on recent literature,2 3 we considered the presence of a blood microbiome very unlikely and did not further venture in this direction. We were therefore extremely excited to read this work, but the results quickly raised concerns in our research group. In another area of microbiota research, we recently …

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    Footnotes

    • Contributors BVHH drafted the response. BVHH, RDZ, QRD and EJK reviewed and approved the response.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests EJK performed research for Cubist, Novartis and Qiagen, and participated in advisory forums of Astellas, Optimer, Actelion, Pfizer, Sanofi Pasteur and Seres Therapeutics. BVHH and EJK received an unrestricted grant from Vedanta Biosciences Inc. The companies and the Netherlands Donor Feces Bank had no role in writing the manuscript.

    • Provenance and peer review Not commissioned; internally peer reviewed.

    • Patient consent for publication Not required.