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Original research
microRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility

Authors

  • Amelia Mazzone Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Peter R Strege Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Simon J Gibbons Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Constanza Alcaino Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Vikram Joshi Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Andrew J Haak Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Daniel J Tschumperlin Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Cheryl E Bernard Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Robert R Cima Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • David W Larson Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Heidi K Chua Department of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Rondell P Graham Department of Pathology, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Mona El Refaey Departments of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA Department of Internal Medicine, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA PubMed articlesGoogle scholar articles
  • Peter J Mohler Departments of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA PubMed articlesGoogle scholar articles
  • Yujiro Hayashi Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Tamas Ordog Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Stefan Calder Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand PubMed articlesGoogle scholar articles
  • Peng Du Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand PubMed articlesGoogle scholar articles
  • Gianrico Farrugia Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  • Arthur Beyder Enteric NeuroScience Program (ENSP), Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Gianrico Farrugia, Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA; farrugia.gianrico{at}mayo.edu; Dr Arthur Beyder, Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, 55905; beyder.arthur{at}mayo.edu
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Citation

Mazzone A, Strege PR, Gibbons SJ, et al
microRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility

Publication history

  • Received March 22, 2019
  • Revised October 16, 2019
  • Accepted November 6, 2019
  • First published November 22, 2019.
Online issue publication 
April 03, 2020

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