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We read with interest the paper by Camilleri and Boeckxstaens1 which summarises the role of mast cells and their mediators in the pathogenesis of functional gastrointestinal disorders, and describes the particular role of histamine action on H1 receptors in submucosal neurons in rectal biopsies, as well as the clinical response to H1 blockade observed in some patients with the IBS.
Mast cells are implicated in both IBS and to a lesser extent in functional dyspepsia.2 These cells release, among other mediators, histamine, which acts on histamine receptors on submucosal neurons, as well as on epithelial cells causing secretion of chloride and bicarbonate.2 Histamine-2 receptor blockade …
Contributors MDEP, TMG, MMW and NJT contributed to the planning, data collection, analysis and preparation of the manuscript for submission. MDEP and NJT were responsible for the overall content as guarantors of the study.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
Patient consent for publication Not required.