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Heterozygous Spink1 c.194+2T>C mutant mice spontaneously develop chronic pancreatitis

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  • CS, ML and WA contributed equally.

  • Contributors CS, ZL and ZSL designed and directed the study. CS, MYL and WA performed experiments and performed data analysis. HJ preformed histological analysis. CS, MYL and WA drafted the manuscript. All authors interpreted the data. XTM, WBZ and HW revised the manuscript. All authors approved the final manuscript.

  • Funding Support for this study came from the National Natural Science Foundation of China (grant numbers 81470885 (CS) and 81670585 (ZSL)), the Scientific Innovation Program of Shanghai Municipal Education Committee (ZL) and the Shuguang Program of Shanghai Education Development Foundation and Municipal Education Commission (grant number 15SG33 (ZL)).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Patient consent for publication Not required.

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