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Contributors All authors have contributed in conception, writing, editing and approving the paper. All authors have provided final approval of the version manuscript. SD has drafted all the figures.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests SD has served as a speaker, consultant and advisory board member for Schering-Plough, Abbott (AbbVie) Laboratories, Merck and Co, UCB Pharma, Ferring, Cellerix, Millenium Takeda, Nycomed, Pharmacosmos, Actelion, Alfa Wasserman, Genentech, Grunenthal, Pfizer, Astra Zeneca, Novo Nordisk, Vifor and Johnson & Johnson. AA as served as Advisory board member of gilead, AbbVie, Intercept, MSD and Alfasigma. AR has served as advisory board member for Medtronic Fuijfilm, Norgine, Boston Scientific, EndoKey, EndoStart, Erbe and Alfasigma.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Commissioned; internally peer reviewed.