Article Text

Download PDFPDF
Authors response: giant oversights in the human gut virome
  1. Tao Zuo,
  2. Siew C Ng
  1. Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
  1. Correspondence to Professor Siew C Ng, Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong; siewchienng{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

We explored gut mucosal virome alterations in UC1 and appreciate the insightful comments from the authors who highlighted some of the important limitations of human gut virome studies.2 Unlike the bacteria microbiome, the gut virome remains largely underexplored. There is currently no gold standard on the optimal pipelines or methods for virome analysis. In addition, the lack of consensus in both methodology and virus taxonomy classification underscores significant limitations and challenges in virome metagenomics analysis.3 4

Most metagenomic studies of the human gut virome have adopted practical methods based on filtration with subsequent precipitation or ultrafiltration of virus-like particles (VLPs).3 Such protocols including that of ours can introduce considerable amounts of residual DNA into the samples, such as …

View Full Text


  • Contributors TZ and SCN performed literature review, data analysis and drafted the response letter.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

  • Patient consent for publication Not required.

Linked Articles