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  • Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet

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Small bowel
Original research
Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet

Authors

  • Ville Wallenius Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Östra, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  • Erik Elias Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  • Erik Elebring Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  • Bauke Haisma Metabolic Research Laboratories, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Anna Casselbrant Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  • Pierre Larraufie Metabolic Research Laboratories, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Emma Spak Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  • Frank Reimann Metabolic Research Laboratories, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Carel W le Roux Diabetes Complications Research Centre, Conway Institute, University College of Dublin, Dublin, Ireland PubMed articlesGoogle scholar articles
  • Neil G Docherty Diabetes Complications Research Centre, Conway Institute, University College of Dublin, Dublin, Ireland PubMed articlesGoogle scholar articles
  • Fiona M Gribble Metabolic Research Laboratories, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Lars Fändriks Department of Gastrosurgical Research and Education, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital/Sahlgrenska, University of Gothenburg, Gothenburg, Sweden PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Ville Wallenius, Dept of Gastrosurgical Research and Education, University of Gothenburg Sahlgrenska Academy, Gothenburg SE-413 45, Sweden; ville.wallenius{at}gastro.gu.se
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Citation

Wallenius V, Elias E, Elebring E, et al
Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet
Gut 2020;69:1423-1431.

Publication history

  • Received June 27, 2019
  • Revised November 4, 2019
  • Accepted November 6, 2019
  • First published November 21, 2019.
Online issue publication 
August 19, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.