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GI symptoms as early signs of COVID-19 in hospitalised Italian patients
  1. Elisabetta Buscarini1,
  2. Guido Manfredi1,
  3. Gianfranco Brambilla1,
  4. Fernanda Menozzi1,
  5. Claudio Londoni1,
  6. Saverio Alicante1,
  7. Elena Iiritano1,
  8. Samanta Romeo1,
  9. Marianna Pedaci1,
  10. Giampaolo Benelli2,
  11. Ciro Canetta3,
  12. Giuseppe La Piana4,
  13. Guido Merli5,
  14. Alessandro Scartabellati6,
  15. Giovanni Viganò7,
  16. Roberto Sfogliarini8,
  17. Giovanni Melilli8,
  18. Roberto Assandri9,
  19. Daniele Cazzato10,
  20. Davide Sebastiano Rossi11,
  21. Susanna Usai11,
  22. Irene Tramacere12,
  23. Germano Pellegata13,
  24. Giuseppe Lauria11,14
  1. 1 Gastroenterology Department, ASST Maggiore Hospital, Crema, Italy
  2. 2 Radiology Department, ASST Maggiore Hospital, Crema, Italy
  3. 3 Emergency Medicine Department, ASST Maggiore Hospital, Crema, Italy
  4. 4 Pneumology 1 Department, ASST Maggiore Hospital, Crema, Italy
  5. 5 Intensive Care Department, ASST Maggiore Hospital, Crema, Italy
  6. 6 Pneumology 2 Department, ASST Maggiore Hospital, Crema, Italy
  7. 7 Emergency Department, ASST Maggiore Hospital, Crema, Italy
  8. 8 Health Directorate, ASST Maggiore Hospital, Crema, Italy
  9. 9 Clinical Investigation Laboratory, ASST Maggiore Hospital, Crema, Italy
  10. 10 Department of Diagnostics and Technology, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy
  11. 11 Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy
  12. 12 Scientific Directorate, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy
  13. 13 General Directorate, ASST Maggiore Hospital, Crema, Italy
  14. 14 Department of Biomedical and Clinical Sciences “Luigi Sacco”, University of Milan, Milan, Italy
  1. Correspondence to Dr Elisabetta Buscarini, Gastroenterology Department, Maggiore Hospital ASST Crema, Largo Dossena 2, Crema 26013, Italy; elisabetta.buscarini{at}asst-crema.it

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In their recent publication in Gut, Lin et al report 11% of patients infected with SARS-CoV-2 (COVID-19) to present at admission with GI symptoms1; early observations reported that COVID-19 could present with GI symptoms in 3% of patients.2 3 Diarrhoea, nausea, vomiting and/or abdominal pain or discomfort have been described at disease onset or even before respiratory symptoms.4–7

We investigated all consecutive individuals suspected to harbour COVID-19 and admitted at the General Hospital of Crema between 21 February and 13 March 2020 to assess prevalence and features of GI symptoms in COVID-19 patients and their correlation with medical history, disease course and outcome.

All suspected individuals admitted to the hospital underwent a standardised work-up. Based on clinical, laboratory and radiological findings, patients were discharged to quarantine or hospitalised. Demographic data, date of onset and type of symptoms at admission, including GI symptoms (as either nausea, or vomiting or diarrhoea or abdominal pain), and hospitalisation …

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