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High-fat, low-carbohydrate diet was associated with unfavourable impact on colonic luminal microenvironment
  1. Yi Wan1,
  2. Duo Li2
  1. 1 Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China
  2. 2 Institute of Nutrition and Health, Qingdao University, Qingdao, China
  1. Correspondence to Professor Duo Li, Institute of Nutrition and Health, Qingdao University, Qingdao 266071, China; duoli{at}

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We thank Ardalan et al for their interest and comments1 on our 6-month randomised controlled feeding trial, in which we have investigated the effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors.2 They indicated that the differences in microbial structure, faecal short-chain fatty acids concentrations and protein fermentation observed in our trial could be explained by the change in carbohydrates, especially the non-digestible carbohydrates like resistant starch (RS) and fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), in company with the change in dietary fat due to the isocaloric design.

Our trial was designed based on the notion that the prevalence of obesity and type 2 diabetes had increased dramatically in parallel with a transition from the traditional low-fat, high-carbohydrates diet to a diet relatively …

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  • Contributors YW and DL wrote this manuscript.

  • Funding This study was funded by the China Postdoctoral Science Foundation (2018M642466 and 2019T12058). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the manuscript.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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