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Contributors Authors contributions: Concept of the study: DP and JW. Provision of laboratory data: OB, KJ and JK. Data analysis: DP, OB, KJ, JK, TB and JW. Preparation of the manuscript: DP and JW. Revision of the manuscript: DP, OB, KJ, JK, TB and JW.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.
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