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Chronic liver disease negatively affects outcome in hospitalised patients with community-acquired pneumonia

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  • Collaborators Members of the CAPNETZ study group: M Dreher, C Cornelissen (Medical Clinic I, University Clinic RWTH Aachen); W Knüppel (Clinic for Internal Medicine, Hospital Bad Arolsen); D Stolz (Clinic for Pneumology, Uni-Spital Basel, Switzerland); N Suttorp, P Creutz, M Witzenrath, A Mikolajewska, A le Claire, M Benzke (Department of Infectious Disease and Respiratory Medicine, Charité-University Medicine, Berlin); T Bauer, D Krieger (HELIOS Klinikum Emil von Behring, Berlin); M Prediger, S Schmager (III. Medical Clinic, Carl-Thiem-Klinikum Cottbus); M Kolditz, B Schulte-Hubbert, S Langner (Medical Department I, Division of Pulmonology, University Hospital Dresden); G Rohde (Medical Clinic I – Pneumology/Allergology, University Hospital Frankfurt); O Degen, A Hüfner (Outpatient Center, University Hospital Hamburg-Eppendorf); C Hoffmann (ICH Study Center, Hamburg); T Welte, J Freise (Department of Respiratory Medicine, Hannover Medical School, Hanover); G Barten-Neiner, M Nawrocki, I Fuge, J Naim, W Kröner (CAPNETZ Office, Hannover); T Illig, N Klopp (Hannover Unified Biobank); C Kroegel, A Moeser (Department of Pneumology & Allergy/Immunology, University Hospital Jena); M Pletz, B Schleenvoigt, C Forstner (Centre for Infection Medicine and Hospital Hygiene (ZIMK), University Hospital, Jena); D Drömann, P Parschke, K Franzen (Med Clinic III, Pulmology, University Hospital Schleswig-Holstein, Lübeck); J Rupp, N Käding (Department of Infectiology and Microbiology, University Hospital Schleswig-Holstein, Lübeck); M Wouters, K Walraven, D Braeken (Department of Respiratory Medicine, Maastricht University Medical Center-MUMC+, Maastricht, The Netherlands); C Spinner (Clinic for Pneumology and General Internal Medicine, Rechts der Isar Hospital, Munich); H Buschmann, A Zaruchas (Medical Clinic-Pneumology, Brüderkrankenhaus St Josef, Paderborn); T Schaberg, I Hering (Center of Pneumology, Diakonie-Hospital Rotenburg); W Albrich, F Waldeck, F Rassouli, S Baldesberger (Department of Infectiology and Hospital Hygiene, Kantonsspital St Gallen, Switzerland); M Panning (University Medical Center Freiburg, Institute of Virology); M Wallner (2mt Software, Ulm); and all study nurses.

  • Contributors Study concept and design: CB, MWP, JR, MW, JT, GGUR. Acquisition, analysis or interpretation of data: CB, MWP, JR, MW, CW, SZ, JT, GGUR. Drafting of the manuscript: CB, JT, GGUR. Critical revision of the manuscript for intellectual content: MWP, JR, MW, CW, SZ.

  • Funding CAPNETZ was funded by a grant from the German Federal Ministry of Education and Research (BMBF grant 01KI07145) 2001–2011.

  • Competing interests MW received research funding outside the submitted work from Biotest, Boehringer Ingelheim, Noxxon, Quark Pharma, Silence Therapeutics and Vaxxilon, and personal fees for lectures or counselling from Actelion, AstraZeneca, Bayer HealthCare, Berlin Chemie, Biotest, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis and Vaxxilon. SZ received consultancy and/or lecture honoraria from AbbVie, Allergan, Intercept, Janssen, Gilead and Merck/MSD. JT received speaking and/or consulting fees from Gore, Bayer, Alexion, MSD, Gilead, Intercept, Norgine, Grifols, Versantis and Martin Pharmaceutical, all unrelated to the submitted work. GGUR reports personal fees from Pfizer, Boehringer Ingelheim, Solvay, GSK, Essex Pharma, MSD, Grifols, Chiesi, Vertex, Roche, Insmed and Novartis for lectures including service on speakers' bureaus outside the submitted work and/or consultancy during advisory board meeting, and personal fees from GSK for travel accommodations/meeting expenses outside the submitted work.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.