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Identifying the factors influencing outcome in probiotic studies in overweight and obese patients: host or microbiome?

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  • Contributors DRM and SFP coordinated the clinical trial and sample collection. BHM, DRM, JAKM and GM undertook the experimental work. All authors were involved in analysis of data and writing the manuscript. All authors approved the final manuscript.

  • Funding Metabonomics studies were performed at the MRC-NIHR National Phenome Centre at Imperial College London; this centre receives financial support from the Medical Research Council (MRC) and National Institute of Health Research (NIHR) (grant number MC_PC_12025). BHM is the recipient of an NIHR Academic Clinical Lectureship. The Division of Digestive Diseases and MRC-NIHR National Phenome Centre at Imperial College London receive financial and infrastructure support from the NIHR Imperial Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London.

  • Competing interests DRM, GM and SFP are/were employees of Cultech Ltd.

  • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.