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Contributors All authors analysed data and wrote the commentary.
Funding This study is supported by Associazione Italiana Ricerca sul Cancro (AIRC 5×1000 n. 12182), Fondazione Cariverona: Oncology Biobank Project 'Antonio Schiavi' (prot. 203885/2017), Fondazione Italiana Malattie Pancreas (FIMP, Ministero Salute, J38D19000690001), Ontario Institute for Cancer Research (PanCuRx Translational Research Initiative) through funding provided by the Government of Ontario, the Wallace McCain Centre for Pancreatic Cancer supported by the Princess Margaret Cancer Foundation, the Terry Fox Research Institute, the Canadian Cancer Society Research Institute and the Pancreatic Cancer Canada Foundation. The study was also supported by a charitable donation from the Canadian Friends of the Hebrew University (Alex U. Soyka).
Competing interests CL has been a paid expert-consultant on microsatellite instability for BioScience Communications (New York, New York, USA).
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Commissioned; internally peer reviewed.