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We have read the paper by Ungaro et al with great interest, in which the authors present an assessment of the association between IBD-related medications and the disease course of COVID-19 based on the Surveillance Epidemiology of Coronavirus Under Research Exclusion for IBD (SECURE-IBD) registry.1 Based on data from 1439 patients from this ongoing multinational registry, the authors confirm their previous suggestion that 5-aminosalicylates and/or sulfasalazine (collectively 5-ASA) might be associated with severe outcomes of COVID-19.2 The authors found that 5-ASA was significantly and independently associated with severe COVID-19 in comparison with patients not receiving 5-ASA and patients receiving monotherapy with tumour necrosis factor antagonists. However, no association was found when comparing with patients not receiving any medication and no dose–response relationship of 5-ASA was observed.
The authors are to be applauded for establishing this innovative registry enabling updated evidence-based decision-making for IBD clinicians. However, as the authors …
Collaborators The Danish COVID-IBD Study Group.
Contributors MA—drafting and preparation of this letter. JS and JB—critical review of the letter. All authors reviewed and approved the final manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.