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Letter
Lack of relationship of AT1001 to zonulin and prehaptoglobin-2: clinical implications
  1. Ludvig M Sollid1,
  2. Frits Koning2
  1. 1 Department of Immunology, University of Oslo, Oslo, Norway
  2. 2 Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to Dr Ludvig M Sollid, Department of Immunology, University of Oslo, Oslo, Norway; l.m.sollid{at}medisin.uio.no; Dr Frits Koning, Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands; f.koning{at}lumc.nl

https://doi.org/10.1136/gutjnl-2020-323829

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    We read with interest the letter to the editor by Massier et al 1 and the accompanying response by Fasano.2 We would like to point out one critical issue that has not been addressed, namely, the relationship between AT1001, zonulin and prehaptoglobin-2. AT1001 is an octapeptide that was thought to represent the N-terminal sequence of zonulin.3 4 However, in all likelihood this octapeptide sequence (GGVLVQPG) derives from immunoglobulin. In their attempt to identify the human homolog of the Vibrio cholera zonula occludens …

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    Footnotes

    • LMS and FK contributed equally.

    • Contributors LS and FK are equal contributors to this article.

    • Funding LMS is funded in part by the Stiftelsen KG Jebsen (SKGJ-MED-017) and a grant from the South-Eastern Norway Regional Health Authority (project #2020027). FK is funded in part by the collaboration project TIMID (LSHM18057-SGF) financed by the PPP allowance made available by Top Sector Life Sciences and Health to Samenwerkende Gezondheidsfondsen (SGF).

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were involved in the design, or conduct, or reporting, or dissemination plans of this research. Refer to the Methods section for further details.

    • Provenance and peer review Not commissioned; internally peer reviewed.